Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058842512> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2058842512 endingPage "1139" @default.
- W2058842512 startingPage "1137" @default.
- W2058842512 abstract "One type of cellular response to hypoxia is an increase in cytosolic Ca2+. VDCCs (voltage-dependent calcium channels) open upon membrane depolarization allowing inward current of Ca2+ ions. Two of the so-called L-type VDCC alpha1 subunits, Ca(v)1.2 and Ca(v)1.3, are found in the brain. We sought to investigate the effect of chronic hypoxia or treatment with a hypoxia-mimicking agent DFX (desferrioxamine mesylate) on expression of L-type VDCC in the SH-SY5Y neuroblastoma cell line. Western blotting identified two atypical forms of the L-type channel with apparent molecular masses of approx. 100 and 150 kDa, compared with typical forms of approx. 200 kDa. Immunofluorescence microscopy shows the approx. 100 kDa protein located within the cell and on the cell surface, while the approx. 150 kDa protein is intracellular with punctate staining. Further analysis revealed that this approx. 150 kDa protein co-localizes with nuclear proteins but not with markers for other intracellular compartments. In addition, these proteins are both down-regulated in DFX-treated and hypoxic cells, suggesting that the mechanism of down-regulation is along the HIF (hypoxia-inducible factor) pathway. This atypical localization of the 150 kDa protein suggests that it might play a role in nuclear calcium signalling in health and disease." @default.
- W2058842512 created "2016-06-24" @default.
- W2058842512 creator A5056053248 @default.
- W2058842512 creator A5058027348 @default.
- W2058842512 creator A5066920774 @default.
- W2058842512 creator A5069103299 @default.
- W2058842512 date "2005-10-26" @default.
- W2058842512 modified "2023-09-23" @default.
- W2058842512 title "Atypical L-type channels are down-regulated in hypoxia" @default.
- W2058842512 cites W1963550141 @default.
- W2058842512 cites W1972523347 @default.
- W2058842512 cites W2034371514 @default.
- W2058842512 cites W2048822395 @default.
- W2058842512 cites W2049485107 @default.
- W2058842512 cites W2169224359 @default.
- W2058842512 cites W4238561464 @default.
- W2058842512 doi "https://doi.org/10.1042/bst0331137" @default.
- W2058842512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16246066" @default.
- W2058842512 hasPublicationYear "2005" @default.
- W2058842512 type Work @default.
- W2058842512 sameAs 2058842512 @default.
- W2058842512 citedByCount "2" @default.
- W2058842512 crossrefType "journal-article" @default.
- W2058842512 hasAuthorship W2058842512A5056053248 @default.
- W2058842512 hasAuthorship W2058842512A5058027348 @default.
- W2058842512 hasAuthorship W2058842512A5066920774 @default.
- W2058842512 hasAuthorship W2058842512A5069103299 @default.
- W2058842512 hasConcept C104317684 @default.
- W2058842512 hasConcept C12554922 @default.
- W2058842512 hasConcept C153911025 @default.
- W2058842512 hasConcept C181199279 @default.
- W2058842512 hasConcept C185592680 @default.
- W2058842512 hasConcept C4141045 @default.
- W2058842512 hasConcept C54355233 @default.
- W2058842512 hasConcept C55493867 @default.
- W2058842512 hasConcept C79879829 @default.
- W2058842512 hasConcept C81885089 @default.
- W2058842512 hasConcept C85265743 @default.
- W2058842512 hasConcept C86803240 @default.
- W2058842512 hasConcept C95444343 @default.
- W2058842512 hasConcept C98539663 @default.
- W2058842512 hasConceptScore W2058842512C104317684 @default.
- W2058842512 hasConceptScore W2058842512C12554922 @default.
- W2058842512 hasConceptScore W2058842512C153911025 @default.
- W2058842512 hasConceptScore W2058842512C181199279 @default.
- W2058842512 hasConceptScore W2058842512C185592680 @default.
- W2058842512 hasConceptScore W2058842512C4141045 @default.
- W2058842512 hasConceptScore W2058842512C54355233 @default.
- W2058842512 hasConceptScore W2058842512C55493867 @default.
- W2058842512 hasConceptScore W2058842512C79879829 @default.
- W2058842512 hasConceptScore W2058842512C81885089 @default.
- W2058842512 hasConceptScore W2058842512C85265743 @default.
- W2058842512 hasConceptScore W2058842512C86803240 @default.
- W2058842512 hasConceptScore W2058842512C95444343 @default.
- W2058842512 hasConceptScore W2058842512C98539663 @default.
- W2058842512 hasIssue "5" @default.
- W2058842512 hasLocation W20588425121 @default.
- W2058842512 hasLocation W20588425122 @default.
- W2058842512 hasOpenAccess W2058842512 @default.
- W2058842512 hasPrimaryLocation W20588425121 @default.
- W2058842512 hasRelatedWork W1488216507 @default.
- W2058842512 hasRelatedWork W1549554643 @default.
- W2058842512 hasRelatedWork W1966079193 @default.
- W2058842512 hasRelatedWork W2004487226 @default.
- W2058842512 hasRelatedWork W2026264997 @default.
- W2058842512 hasRelatedWork W2071063451 @default.
- W2058842512 hasRelatedWork W2082869541 @default.
- W2058842512 hasRelatedWork W2109748156 @default.
- W2058842512 hasRelatedWork W2468790316 @default.
- W2058842512 hasRelatedWork W4283166397 @default.
- W2058842512 hasVolume "33" @default.
- W2058842512 isParatext "false" @default.
- W2058842512 isRetracted "false" @default.
- W2058842512 magId "2058842512" @default.
- W2058842512 workType "article" @default.