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- W2058846596 abstract "Optimization of the chromatographic separation of antipyretic mixtures is described. A function of mutual information, FUMI, based on information theory and the Kalman filter, is used as the criterion. The separation patterns are predicted on the basis of the model that relates the logarithm of the capacity factor, log (k′), of a solute to the volume fraction of the organic modifier in the mobile phase by a second-order equation. Overlapped chromatograms and single chromatograms were simulated and evaluated by the separation time and the FUMI. Optimal conditions were selected two-dimensionally with respect to mobile-phase composition and injection interval and then confirmed by experiments." @default.
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- W2058846596 date "1989-01-01" @default.
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- W2058846596 title "Use of a function of mutual information for optimization of mobile-phase composition in reversed-phase liquid chromatography" @default.
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- W2058846596 doi "https://doi.org/10.1016/s0003-2670(00)81905-4" @default.
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