FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058858073> ?p ?o ?g. }

• W2058858073 endingPage "274" @default.
• W2058858073 startingPage "263" @default.
• W2058858073 abstract "Epstein-Barr virus (EBV) and the closely related Herpesvirus papio (HVP) are stably replicated as episomes in proliferating latently infected cells. Maintenance and partitioning of these viral plasmids requires a viral sequence in cis, termed the family of repeats (FR), that is bound by a viral protein, Epstein-Barr nuclear antigen 1 (EBNA1). Upon binding FR, EBNA1 maintains viral genomes in proliferating cells and activates transcription from viral promoters required for immortalization. FR from either virus encodes multiple binding sites for the viral maintenance protein, EBNA1, with the FR from the prototypic B95-8 strain of EBV containing 20 binding sites, and FR from HVP containing 8 binding sites. In addition to differences in the number of EBNA1-binding sites, adjacent binding sites in the EBV FR are typically separated by 14 base pairs (bp), but are separated by 10 bp in HVP. We tested whether the number of binding sites, as well as the distance between adjacent binding sites, affects the function of EBNA1 in transcription activation or plasmid maintenance. Our results indicate that EBNA1 activates transcription more efficiently when adjacent binding sites are separated by 10 bp, the spacing observed in HVP. In contrast, using two separate assays, we demonstrate that plasmid maintenance is greatly augmented when adjacent EBNA1-binding sites are separated by 14 bp, and therefore, presumably lie on the same face of the DNA double helix. These results provide indication that the functions of EBNA1 in transcription activation and plasmid maintenance are separable." @default.
• W2058858073 created "2016-06-24" @default.
• W2058858073 creator A5041409431 @default.
• W2058858073 creator A5066194338 @default.
• W2058858073 creator A5067672637 @default.
• W2058858073 creator A5086722931 @default.
• W2058858073 date "2003-07-01" @default.
• W2058858073 modified "2023-09-27" @default.
• W2058858073 title "The spacing between adjacent binding sites in the family of repeats affects the functions of Epstein–Barr nuclear antigen 1 in transcription activation and stable plasmid maintenance" @default.
• W2058858073 cites W1486001308 @default.
• W2058858073 cites W1526922416 @default.
• W2058858073 cites W1594478849 @default.
• W2058858073 cites W1649138245 @default.
• W2058858073 cites W1786573368 @default.
• W2058858073 cites W1801738628 @default.
• W2058858073 cites W1827441151 @default.
• W2058858073 cites W1874041651 @default.
• W2058858073 cites W1888245696 @default.
• W2058858073 cites W1980464074 @default.
• W2058858073 cites W1981922425 @default.
• W2058858073 cites W1985971484 @default.
• W2058858073 cites W1991185690 @default.
• W2058858073 cites W2003750162 @default.
• W2058858073 cites W2013597873 @default.
• W2058858073 cites W2034220289 @default.
• W2058858073 cites W2044296969 @default.
• W2058858073 cites W2045327902 @default.
• W2058858073 cites W2047197428 @default.
• W2058858073 cites W2072457100 @default.
• W2058858073 cites W2078682316 @default.
• W2058858073 cites W2085145057 @default.
• W2058858073 cites W2096591944 @default.
• W2058858073 cites W2099455371 @default.
• W2058858073 cites W2104605112 @default.
• W2058858073 cites W2106295967 @default.
• W2058858073 cites W2107975705 @default.
• W2058858073 cites W2109290075 @default.
• W2058858073 cites W2126466006 @default.
• W2058858073 cites W2131770121 @default.
• W2058858073 cites W2135647597 @default.
• W2058858073 cites W2143118331 @default.
• W2058858073 cites W2143458241 @default.
• W2058858073 cites W2144753766 @default.
• W2058858073 cites W2147725019 @default.
• W2058858073 cites W2148080727 @default.
• W2058858073 cites W2168888321 @default.
• W2058858073 cites W2175305763 @default.
• W2058858073 cites W2415785574 @default.
• W2058858073 cites W4251718946 @default.
• W2058858073 cites W79384053 @default.
• W2058858073 doi "https://doi.org/10.1016/s0042-6822(03)00122-3" @default.
• W2058858073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2922029" @default.
• W2058858073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12842617" @default.
• W2058858073 hasPublicationYear "2003" @default.
• W2058858073 type Work @default.
• W2058858073 sameAs 2058858073 @default.
• W2058858073 citedByCount "19" @default.
• W2058858073 countsByYear W20588580732012 @default.
• W2058858073 countsByYear W20588580732013 @default.
• W2058858073 countsByYear W20588580732014 @default.
• W2058858073 countsByYear W20588580732022 @default.
• W2058858073 crossrefType "journal-article" @default.
• W2058858073 hasAuthorship W2058858073A5041409431 @default.
• W2058858073 hasAuthorship W2058858073A5066194338 @default.
• W2058858073 hasAuthorship W2058858073A5067672637 @default.
• W2058858073 hasAuthorship W2058858073A5086722931 @default.
• W2058858073 hasBestOaLocation W20588580732 @default.
• W2058858073 hasConcept C101762097 @default.
• W2058858073 hasConcept C104317684 @default.
• W2058858073 hasConcept C107824862 @default.
• W2058858073 hasConcept C138885662 @default.
• W2058858073 hasConcept C150194340 @default.
• W2058858073 hasConcept C153911025 @default.
• W2058858073 hasConcept C159047783 @default.
• W2058858073 hasConcept C179926584 @default.
• W2058858073 hasConcept C22744801 @default.
• W2058858073 hasConcept C3662595 @default.
• W2058858073 hasConcept C41895202 @default.
• W2058858073 hasConcept C54355233 @default.
• W2058858073 hasConcept C552990157 @default.
• W2058858073 hasConcept C86339819 @default.
• W2058858073 hasConcept C86803240 @default.
• W2058858073 hasConcept C94966510 @default.
• W2058858073 hasConcept C95444343 @default.
• W2058858073 hasConceptScore W2058858073C101762097 @default.
• W2058858073 hasConceptScore W2058858073C104317684 @default.
• W2058858073 hasConceptScore W2058858073C107824862 @default.
• W2058858073 hasConceptScore W2058858073C138885662 @default.
• W2058858073 hasConceptScore W2058858073C150194340 @default.
• W2058858073 hasConceptScore W2058858073C153911025 @default.
• W2058858073 hasConceptScore W2058858073C159047783 @default.
• W2058858073 hasConceptScore W2058858073C179926584 @default.
• W2058858073 hasConceptScore W2058858073C22744801 @default.
• W2058858073 hasConceptScore W2058858073C3662595 @default.
• W2058858073 hasConceptScore W2058858073C41895202 @default.
• W2058858073 hasConceptScore W2058858073C54355233 @default.
• W2058858073 hasConceptScore W2058858073C552990157 @default.
• W2058858073 hasConceptScore W2058858073C86339819 @default.

• next