FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058872521> ?p ?o ?g. }

• W2058872521 endingPage "n/a" @default.
• W2058872521 startingPage "n/a" @default.
• W2058872521 abstract "We have previously described two types of protective B-cell epitopes in the O-antigen (OAg) of the Gram-negative bacterium Francisella tularensis: repeating internal epitopes targeted by the vast majority of anti-OAg monoclonal antibodies (mAbs), and a non-overlapping epitope at the non-reducing end targeted by the previously unique IgG2a mAb FB11. We have now generated and characterized three mAbs specific for the non-reducing end of F. tularensis OAg, partially encoded by the same variable region germline genes, indicating that they target the same epitope. Like FB11, the new mAbs, Ab63 (IgG3), N213 (IgG3) and N62 (IgG2b), had higher antigen-binding bivalent avidity than internally binding anti-OAg mAbs, and an oligosaccharide containing a single OAg repeat was sufficient for optimal inhibition of their antigen-binding. The X-ray crystal structure of N62 Fab showed that the antigen-binding site is lined mainly by aromatic amino acids that form a small cavity, which can accommodate no more than one and a third sugar residues, indicating that N62 binds mainly to the terminal Qui4NFm residue at the nonreducing end of OAg. In efficacy studies with mice infected intranasally with the highly virulent F. tularensis strain SchuS4, N62, N213 and Ab63 prolonged survival and reduced blood bacterial burden. These results yield insights into how antibodies to non-reducing ends of microbial polysaccharides can contribute to immune protection despite the smaller size of their target epitopes compared with antibodies to internal polysaccharide regions." @default.
• W2058872521 created "2016-06-24" @default.
• W2058872521 creator A5003615763 @default.
• W2058872521 creator A5007669776 @default.
• W2058872521 creator A5008508346 @default.
• W2058872521 creator A5010218385 @default.
• W2058872521 creator A5013242108 @default.
• W2058872521 creator A5025958612 @default.
• W2058872521 creator A5050064409 @default.
• W2058872521 creator A5051318955 @default.
• W2058872521 creator A5061502860 @default.
• W2058872521 creator A5066116017 @default.
• W2058872521 date "2013-07-01" @default.
• W2058872521 modified "2023-10-11" @default.
• W2058872521 title "The binding sites of monoclonal antibodies to the nonreducing end ofFrancisella tularensis O-antigen accommodate mainly the terminal saccharide" @default.
• W2058872521 cites W1244099196 @default.
• W2058872521 cites W1503988225 @default.
• W2058872521 cites W1512600567 @default.
• W2058872521 cites W1523765851 @default.
• W2058872521 cites W1539796472 @default.
• W2058872521 cites W1597899312 @default.
• W2058872521 cites W1727595591 @default.
• W2058872521 cites W1864472282 @default.
• W2058872521 cites W1915355792 @default.
• W2058872521 cites W1959087976 @default.
• W2058872521 cites W1967965427 @default.
• W2058872521 cites W1968584725 @default.
• W2058872521 cites W1974869964 @default.
• W2058872521 cites W1975113791 @default.
• W2058872521 cites W1977521262 @default.
• W2058872521 cites W1978499958 @default.
• W2058872521 cites W1993019335 @default.
• W2058872521 cites W1993815277 @default.
• W2058872521 cites W2002397167 @default.
• W2058872521 cites W2002871661 @default.
• W2058872521 cites W2003130485 @default.
• W2058872521 cites W2005912873 @default.
• W2058872521 cites W2008318905 @default.
• W2058872521 cites W2012283585 @default.
• W2058872521 cites W2012602566 @default.
• W2058872521 cites W2025880445 @default.
• W2058872521 cites W2031394441 @default.
• W2058872521 cites W2031417773 @default.
• W2058872521 cites W2035007438 @default.
• W2058872521 cites W2037958927 @default.
• W2058872521 cites W2039279250 @default.
• W2058872521 cites W2042903553 @default.
• W2058872521 cites W2049177491 @default.
• W2058872521 cites W2051090776 @default.
• W2058872521 cites W2062007418 @default.
• W2058872521 cites W2063618084 @default.
• W2058872521 cites W2071846790 @default.
• W2058872521 cites W2072854137 @default.
• W2058872521 cites W2076303995 @default.
• W2058872521 cites W2082466940 @default.
• W2058872521 cites W2084106863 @default.
• W2058872521 cites W2086533653 @default.
• W2058872521 cites W2088652385 @default.
• W2058872521 cites W2095336660 @default.
• W2058872521 cites W2105437330 @default.
• W2058872521 cites W2124279100 @default.
• W2058872521 cites W2131612579 @default.
• W2058872521 cites W2138379578 @default.
• W2058872521 cites W2143467722 @default.
• W2058872521 cites W2144081223 @default.
• W2058872521 cites W2149120149 @default.
• W2058872521 cites W2159934584 @default.
• W2058872521 cites W2165043284 @default.
• W2058872521 cites W2167186671 @default.
• W2058872521 cites W2167960824 @default.
• W2058872521 cites W2171333660 @default.
• W2058872521 cites W2171677744 @default.
• W2058872521 cites W2171987220 @default.
• W2058872521 cites W2180229411 @default.
• W2058872521 cites W2394550688 @default.
• W2058872521 cites W2398472574 @default.
• W2058872521 doi "https://doi.org/10.1111/imm.12150" @default.
• W2058872521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3800442" @default.
• W2058872521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23844703" @default.
• W2058872521 hasPublicationYear "2013" @default.
• W2058872521 type Work @default.
• W2058872521 sameAs 2058872521 @default.
• W2058872521 citedByCount "10" @default.
• W2058872521 countsByYear W20588725212013 @default.
• W2058872521 countsByYear W20588725212014 @default.
• W2058872521 countsByYear W20588725212015 @default.
• W2058872521 countsByYear W20588725212016 @default.
• W2058872521 countsByYear W20588725212017 @default.
• W2058872521 countsByYear W20588725212021 @default.
• W2058872521 countsByYear W20588725212022 @default.
• W2058872521 crossrefType "journal-article" @default.
• W2058872521 hasAuthorship W2058872521A5003615763 @default.
• W2058872521 hasAuthorship W2058872521A5007669776 @default.
• W2058872521 hasAuthorship W2058872521A5008508346 @default.
• W2058872521 hasAuthorship W2058872521A5010218385 @default.
• W2058872521 hasAuthorship W2058872521A5013242108 @default.
• W2058872521 hasAuthorship W2058872521A5025958612 @default.
• W2058872521 hasAuthorship W2058872521A5050064409 @default.

• next