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- W2058878835 endingPage "E54" @default.
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- W2058878835 abstract "A high proportion of intramammary coliform infections present at parturition develop disease characterized by severe inflammatory signs and sepsis during the first 60 to 70 d of lactation. In the lactating bovine mammary gland, the innate immune system plays a critical role in determining the outcome of these infections. Since the beginning of the 1990s, research has increased significantly on bovine mammary innate defense mechanisms in connection with the pathogenesis of coliform mastitis. Neutrophils are key effector cells of the innate immune response to intramammary infection, and their function is influenced by many physiological events that occur during the transition period. Opportunistic infections occur when the integrity of the host immune system is compromised by physical and physiological conditions that make the host more susceptible. The innate immune system of many periparturient cows is immunocompromised. It is unlikely that periparturient immunosuppression is the result of a single physiological factor; more likely, several entities act in concert, with profound effects on the function of many organ systems of the periparturient dairy cow. Their defense system is unable to modulate the complex network of innate immune responses, leading to incomplete resolution of the pathogen and the inflammatory reaction. During the last 30 yr, most efforts have been focused on neutrophil diapedesis, phagocytosis, and bacterial killing. How these functions modulate the clinical outcome of coliform mastitis, and how they can be influenced by hormones and metabolism has been the subject of intensive research and is the focus of this review. The afferent (sensing) arm of innate immunity, which enables host recognition of a diverse array of pathogens, is the subject of intense research interest and may contribute to the variable inflammatory response to intramammary infections during different stages of lactation. The development of novel interventions that modulate the inflammatory response or contribute to the elimination of the pathogen or both may offer therapeutic promise in the treatment of mastitis in periparturient cows." @default.
- W2058878835 created "2016-06-24" @default.
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- W2058878835 date "2007-06-01" @default.
- W2058878835 modified "2023-09-30" @default.
- W2058878835 title "Cumulative Physiological Events Influence the Inflammatory Response of the Bovine Udder to Escherichia coli Infections During the Transition Period" @default.
- W2058878835 cites W1487188207 @default.
- W2058878835 cites W1506754512 @default.
- W2058878835 cites W1511204912 @default.
- W2058878835 cites W15642971 @default.
- W2058878835 cites W1618819787 @default.
- W2058878835 cites W164586581 @default.
- W2058878835 cites W1712997642 @default.
- W2058878835 cites W1849604893 @default.
- W2058878835 cites W1963700544 @default.
- W2058878835 cites W1963910270 @default.
- W2058878835 cites W1964710766 @default.
- W2058878835 cites W1964981381 @default.
- W2058878835 cites W1966007943 @default.
- W2058878835 cites W1966943661 @default.
- W2058878835 cites W1971772340 @default.
- W2058878835 cites W1974650703 @default.
- W2058878835 cites W1980172779 @default.
- W2058878835 cites W1982576479 @default.
- W2058878835 cites W1984513526 @default.
- W2058878835 cites W1984664458 @default.
- W2058878835 cites W1986827927 @default.
- W2058878835 cites W1987090542 @default.
- W2058878835 cites W1987760970 @default.
- W2058878835 cites W1995496862 @default.
- W2058878835 cites W1996150839 @default.
- W2058878835 cites W1997940898 @default.
- W2058878835 cites W1999096587 @default.
- W2058878835 cites W2000696348 @default.
- W2058878835 cites W2000817432 @default.
- W2058878835 cites W2002005796 @default.
- W2058878835 cites W2004026458 @default.
- W2058878835 cites W2006179336 @default.
- W2058878835 cites W2012262642 @default.
- W2058878835 cites W2014635586 @default.
- W2058878835 cites W2014765506 @default.
- W2058878835 cites W2017168436 @default.
- W2058878835 cites W2017303867 @default.
- W2058878835 cites W2017579409 @default.
- W2058878835 cites W2020036817 @default.
- W2058878835 cites W2020715415 @default.
- W2058878835 cites W2020887676 @default.
- W2058878835 cites W2020969008 @default.
- W2058878835 cites W2021704370 @default.
- W2058878835 cites W2024235705 @default.
- W2058878835 cites W2024915476 @default.
- W2058878835 cites W2025339129 @default.
- W2058878835 cites W2026327335 @default.
- W2058878835 cites W2027961711 @default.
- W2058878835 cites W2030393676 @default.
- W2058878835 cites W2031551693 @default.
- W2058878835 cites W2034532897 @default.
- W2058878835 cites W2035409717 @default.
- W2058878835 cites W2035626265 @default.
- W2058878835 cites W2040282922 @default.
- W2058878835 cites W2040745169 @default.
- W2058878835 cites W2042317672 @default.
- W2058878835 cites W2046634638 @default.
- W2058878835 cites W2048638452 @default.
- W2058878835 cites W2051425777 @default.
- W2058878835 cites W2053189652 @default.
- W2058878835 cites W2055608312 @default.
- W2058878835 cites W2056054587 @default.
- W2058878835 cites W2057814108 @default.
- W2058878835 cites W2060188605 @default.
- W2058878835 cites W2062229108 @default.
- W2058878835 cites W2066430440 @default.
- W2058878835 cites W2067263548 @default.
- W2058878835 cites W2067328369 @default.
- W2058878835 cites W2069009451 @default.
- W2058878835 cites W2071838076 @default.
- W2058878835 cites W2075702856 @default.
- W2058878835 cites W2078563613 @default.
- W2058878835 cites W2078841464 @default.
- W2058878835 cites W2080462805 @default.
- W2058878835 cites W2083762633 @default.
- W2058878835 cites W2084923510 @default.
- W2058878835 cites W2084941011 @default.
- W2058878835 cites W2094054189 @default.
- W2058878835 cites W2095013444 @default.
- W2058878835 cites W2098947142 @default.
- W2058878835 cites W2101489834 @default.
- W2058878835 cites W2104934425 @default.
- W2058878835 cites W2108480572 @default.
- W2058878835 cites W2109168147 @default.
- W2058878835 cites W2110070549 @default.
- W2058878835 cites W2110527323 @default.