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• W2058884014 startingPage "9699" @default.
• W2058884014 abstract "Ulcerative colitis and Crohn's disease are the major phenotypes of the idiopathic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms, impairing function and quality of life. Current medications are aimed at reducing the symptoms or suppressing exacerbations. However, patients require life-long medications, and this can lead to drug dependency, loss of response together with adverse side effects. Indeed, drug side effects become additional morbidity factor in many patients on long-term medications. Nonetheless, the efficacy of anti-tumour necrosis factors (TNF)-α biologics has validated the role of inflammatory cytokines notably TNF-α in the exacerbation of IBD. However, inflammatory cytokines are released by patients' own cellular elements including myeloid lineage leucocytes, which in patients with IBD are elevated with activation behaviour and prolonged survival. Accordingly, these leucocytes appear logical targets of therapy and can be depleted by adsorptive granulocyte/monocyte apheresis (GMA) with an Adacolumn. Based on this background, recently GMA has been applied to treat patients with IBD in Japan and in the European Union countries. Efficacy rates have been impressive as well as disappointing. In fact the clinical response to GMA seems to define the patients' disease course, response to medications, duration of active disease, and severity at entry. The best responders have been first episode cases (up to 100%) followed by steroid naïve and patients with a short duration of active disease prior to GMA. Patients with deep ulcers together with extensive loss of the mucosal tissue and cases with a long duration of IBD refractory to existing medications are not likely to benefit from GMA. It is clinically interesting that patients who respond to GMA have a good long-term disease course by avoiding drugs including corticosteroids in the early stage of their IBD. Additionally, GMA is very much favoured by patients for its good safety profile. GMA in 21st century reminds us of phlebotomy as a major medical practice at the time of Hippocrates. However, in patients with IBD, there is a scope for removing from the body the sources of pro-inflammatory cytokines and achieve disease remission. The bottom line is that by introducing GMA at an early stage following the onset of IBD or before patients develop extensive mucosal damage and become refractory to medications, many patients should respond to GMA and avoid pharmacologics. This should fulfill the desire to treat without drugs." @default.
• W2058884014 created "2016-06-24" @default.
• W2058884014 creator A5042956748 @default.
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• W2058884014 date "2014-01-01" @default.
• W2058884014 modified "2023-10-12" @default.
• W2058884014 title "Treating inflammatory bowel disease by adsorptive leucocytapheresis: A desire to treat without drugs" @default.
• W2058884014 cites W128319143 @default.
• W2058884014 cites W1513433299 @default.
• W2058884014 cites W1526627739 @default.
• W2058884014 cites W1539312716 @default.
• W2058884014 cites W1843989750 @default.
• W2058884014 cites W1964562488 @default.
• W2058884014 cites W1964593079 @default.
• W2058884014 cites W1967970880 @default.
• W2058884014 cites W1969511625 @default.
• W2058884014 cites W1971685694 @default.
• W2058884014 cites W1972076324 @default.
• W2058884014 cites W1972640453 @default.
• W2058884014 cites W1973694543 @default.
• W2058884014 cites W1974522884 @default.
• W2058884014 cites W1977554333 @default.
• W2058884014 cites W1984802220 @default.
• W2058884014 cites W1985462428 @default.
• W2058884014 cites W1987064800 @default.
• W2058884014 cites W1987925515 @default.
• W2058884014 cites W1987974049 @default.
• W2058884014 cites W1989347679 @default.
• W2058884014 cites W1989658278 @default.
• W2058884014 cites W1991340166 @default.
• W2058884014 cites W1992650609 @default.
• W2058884014 cites W1994019537 @default.
• W2058884014 cites W1995575265 @default.
• W2058884014 cites W1995735465 @default.
• W2058884014 cites W1996981713 @default.
• W2058884014 cites W1998669743 @default.
• W2058884014 cites W2001187233 @default.
• W2058884014 cites W2003099302 @default.
• W2058884014 cites W2003492229 @default.
• W2058884014 cites W2003888527 @default.
• W2058884014 cites W2004317303 @default.
• W2058884014 cites W2006438249 @default.
• W2058884014 cites W2008564793 @default.
• W2058884014 cites W2008859350 @default.
• W2058884014 cites W2012812522 @default.
• W2058884014 cites W2017059356 @default.
• W2058884014 cites W2018031156 @default.
• W2058884014 cites W2022301064 @default.
• W2058884014 cites W2025207379 @default.
• W2058884014 cites W2025513474 @default.
• W2058884014 cites W2026545194 @default.
• W2058884014 cites W2030638936 @default.
• W2058884014 cites W2031882144 @default.
• W2058884014 cites W2032050090 @default.
• W2058884014 cites W2032402174 @default.
• W2058884014 cites W2039455576 @default.
• W2058884014 cites W2043004968 @default.
• W2058884014 cites W2043530745 @default.
• W2058884014 cites W2050011892 @default.
• W2058884014 cites W2051705544 @default.
• W2058884014 cites W2057264565 @default.
• W2058884014 cites W2057751431 @default.
• W2058884014 cites W2060081626 @default.
• W2058884014 cites W2061993550 @default.
• W2058884014 cites W2062158354 @default.
• W2058884014 cites W2064305620 @default.
• W2058884014 cites W2067668368 @default.
• W2058884014 cites W2071748269 @default.
• W2058884014 cites W2073387523 @default.
• W2058884014 cites W2075836508 @default.
• W2058884014 cites W2078621117 @default.
• W2058884014 cites W2078640127 @default.
• W2058884014 cites W2080555804 @default.
• W2058884014 cites W2081134502 @default.
• W2058884014 cites W2085318733 @default.
• W2058884014 cites W2086203819 @default.
• W2058884014 cites W2086590566 @default.
• W2058884014 cites W2087461697 @default.
• W2058884014 cites W2088770096 @default.
• W2058884014 cites W2093588767 @default.
• W2058884014 cites W2099460562 @default.
• W2058884014 cites W2102973745 @default.
• W2058884014 cites W2109712624 @default.
• W2058884014 cites W2111045741 @default.
• W2058884014 cites W2112550484 @default.
• W2058884014 cites W2116422482 @default.
• W2058884014 cites W2119500208 @default.
• W2058884014 cites W2123537724 @default.
• W2058884014 cites W2124711796 @default.
• W2058884014 cites W2127281820 @default.
• W2058884014 cites W2127742687 @default.
• W2058884014 cites W2129155917 @default.
• W2058884014 cites W2129810681 @default.
• W2058884014 cites W2130865756 @default.

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