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- W2058897373 abstract "Temperature-sensitive (ts) transformation mutants of Moloney murine sarcoma virus were isolated from uv-irradiated viral stocks using a selection and screening procedure based on the ability of MSV-transformed NRK cells to grow in methyl cellulose or agar suspension. Mutants isolated by this procedure formed colonies in agar 1000- to 10,000-fold more efficiently at 34° than at 39°. They also exhibited a transformed morphology and elevated hexose transport levels at 34°, but were phenotypically normal at 39°. Both morphology and hexose transport showed transformed → normal and normal → transformed conversion within 12–48 hr of a temperature shift from 34 to 39° and 39 to 34° respectively. In contrast, ts-transformed cells suspended in agar and incubated at 39° for 24 hr showed a 90% reduction in colony-forming ability when the plates were returned to 34°. Superinfection of nonproducer ts-transformed cells with leukemia virus resulted in the rescue of ts MSV. Rescued supernatants also contained a high proportion (10%) of wt MSV. Repeated cloning of ts mutants, either as virus or cells, did not significantly affect the proportion of ts or wt virus rescued. The ability of ts-transformed cells to express the transformed phenotype at 39° could be restored by wt MSV superinfection, but not by MLV superinfection." @default.
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- W2058897373 title "The isolation and preliminary characterization of temperature-sensitive transformation mutants of Moloney sarcoma virus" @default.
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- W2058897373 doi "https://doi.org/10.1016/0042-6822(79)90486-0" @default.
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