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• W2058899668 abstract "Abstract In this study, we investigated the effect of the extracellular matrix (ECM) secreted by vascular cells on proteoglycan (PG) synthesis by vascular smooth muscle cells in culture. PG synthesis of human aortic smooth muscle cells plated on plastic or the matrices derived from vascular endothelial cells, vascular smooth muscle cells, or THP‐1 macrophages was characterized. Smooth muscle cell and macrophage matrices increased both secreted and cellular smooth muscle cells PG production by 2.5‐fold to 3.9‐fold, respectively, over plastic and endothelial cell matrix. Macrophage matrix was more potent than smooth muscle cell matrix in this regard. Selective enzymatic removal of chondroitin sulfates, collagen, and elastin from smooth muscle cell matrix enhanced the stimulation of PG synthesis, as did the removal of chondroitin sulfates from macrophage matrix. PG turnover rates were similar for smooth muscle cells plated on the three matrices. The newly synthesized PG from cultures plated on smooth muscle cell‐, and macrophage‐derived matrices had greater charge density, larger molecular size, and longer glycosaminoglycan chains than those from endothelial cell matrix cultures. These data show that the ECM plays a major role in modulating vascular smooth muscle cell PG metabolism in vitro. J. Cell. Physiol. 198: 302–309, 2004© 2003 Wiley‐Liss, Inc." @default.
• W2058899668 created "2016-06-24" @default.
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• W2058899668 date "2003-10-28" @default.
• W2058899668 modified "2023-10-10" @default.
• W2058899668 title "Modulation of vascular smooth muscle cells proteoglycan synthesis by the extracellular matrix" @default.
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• W2058899668 doi "https://doi.org/10.1002/jcp.10414" @default.
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