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- W2058902492 abstract "6-Thioguanine (6-TG) and 6-mercaptopurine (6-MP) have been reported to produce cytotoxicity due to incorporation into DNA. Although some investigators have performed in vitro transcription studies with synthetic polymers containing 6-TG, the DNA isolated from a cell population exposed to thiopurines has not been evaluated for its biological activity. Bacillus subtilis UTH-8505 was grown in the presence of 6-TG, 6-MP, bromodeoxyuridine (BUdR), arabinosyladenine (AraA) and 2,6-diaminopurine. DNA isolated from these and control cultures was used to transform B. subtilis T3, a strain lacking tryptophan synthetase, to prototrophy. 6-MP exposure decreased the transforming activity 80 per cent; 6-TG, 20 per cent; BUdR, 50 per cent; and in single determinations AraA and 2,4-diaminopurine were without effect. 6-MP was also the most effective growth inhibitor of B. subtilis. Base composition and melting temperatures of the DNA from 6-MP, 6-TG and BUdR cultures were not altered. Although the methods employed did not permit unequivocal demonstration of 6-TG incorporation, a maximal estimate of one 6-TG molecule substituted for every 500 guanine residues in the DNA was inferred. Thus, extremely low levels of incorporation may alter DNA function, or the reduced transforming activity is produced by another mechanism." @default.
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- W2058902492 date "1979-04-01" @default.
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- W2058902492 title "Effects of 6-thiopurines on the transforming activity of Bacillus subtilis deoxyribonucleic acid" @default.
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- W2058902492 doi "https://doi.org/10.1016/0006-2952(79)90324-1" @default.
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