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- W2058902621 abstract "A complementary DNA (cDNA) clone encoding chicken insulin-like growth factor binding protein-5 (cIGFBP-5) was isolated. The nucleotide sequence of the 1236-bp clone encodes a mature polypeptide of 251 amino acids with a calculated molecular weight of approximately 28.2 kDa. The deduced amino acid sequence is 83% identical to human IGFBP-5. Labeled cIGFBP-5 cDNA detected a single mRNA transcript of approximately 6 kb by Northern blot analysis of various tissues obtained from embryonic and 6 weeks post-hatch chickens; interestingly, adult heart showed an approximately 10-fold increase in cIGFBP-5 mRNA relative to embryonic heart. The pattern of IGFBP-5 mRNA expression in chicken tissues was similar to that found in mammals during fetal and extrauterine life. In addition, IGFBP-5 mRNA was abundant in primary cultures of chicken myoblasts throughout in vitro differentiation and fusion. The conservation of IGFBP-5 primary structure and expression pattern across vertebrate species suggests conservation of important functions during evolution, particularly in muscle differentiation." @default.
- W2058902621 created "2016-06-24" @default.
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- W2058902621 date "1997-04-01" @default.
- W2058902621 modified "2023-10-02" @default.
- W2058902621 title "Chicken Insulin-like Growth Factor Binding Protein (IGFBP)-5: Conservation of IGFBP-5 Structure and Expression During Evolution" @default.
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- W2058902621 doi "https://doi.org/10.1016/s0305-0491(96)00289-1" @default.
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