FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058902845> ?p ?o ?g. }

• W2058902845 endingPage "839" @default.
• W2058902845 startingPage "827" @default.
• W2058902845 abstract "Protection of skin against UV light requires a coordinated interaction between melanocytes and keratinocytes. Melanosomes are lysosome-related organelles that originate in melanocytes and are transferred into keratinocytes where they form a supranuclear cap. The mechanism responsible for melanosome transfer into keratinocytes and their intracellular distribution is poorly understood. Recently, we reported for the first time that loss-of-function mutations in the keratin K5 gene affect melanosome distribution in keratinocytes and results in a reticulate hyperpigmentation disorder, called Dowling-Degos disease. Here, we characterise the distribution and behaviour of individual K5 and K14 domains following transient and stable transfection into cells. We report that the K5 head domain is considerably more stable than the K14 head. Moreover, the distribution of the K5 head domain is altered following depolymerisation of microtubules. Following co-immunoprecipitation, we verified a specific interaction between the head domain of K5 with Hsc70, a chaperone also involved in vesicle uncoating. We hypothesise that this interaction is involved in melanosome formation or transport in keratinocytes. Alternatively, it may have a general function in the regulation of keratin assembly." @default.
• W2058902845 created "2016-06-24" @default.
• W2058902845 creator A5002110691 @default.
• W2058902845 creator A5008405084 @default.
• W2058902845 creator A5027124617 @default.
• W2058902845 creator A5037306910 @default.
• W2058902845 creator A5038633678 @default.
• W2058902845 creator A5041640381 @default.
• W2058902845 creator A5044128159 @default.
• W2058902845 creator A5057176287 @default.
• W2058902845 creator A5089414900 @default.
• W2058902845 date "2007-12-01" @default.
• W2058902845 modified "2023-09-23" @default.
• W2058902845 title "Identification of a keratin-associated protein with a putative role in vesicle transport" @default.
• W2058902845 cites W1940477445 @default.
• W2058902845 cites W1965917412 @default.
• W2058902845 cites W1968321832 @default.
• W2058902845 cites W1969921542 @default.
• W2058902845 cites W1982155714 @default.
• W2058902845 cites W1999819298 @default.
• W2058902845 cites W2001394865 @default.
• W2058902845 cites W2007631619 @default.
• W2058902845 cites W2012614451 @default.
• W2058902845 cites W2018115687 @default.
• W2058902845 cites W2028094847 @default.
• W2058902845 cites W2036391288 @default.
• W2058902845 cites W2038734979 @default.
• W2058902845 cites W2042203410 @default.
• W2058902845 cites W2043485308 @default.
• W2058902845 cites W2047427411 @default.
• W2058902845 cites W2072389814 @default.
• W2058902845 cites W2084883783 @default.
• W2058902845 cites W2089061164 @default.
• W2058902845 cites W2103651337 @default.
• W2058902845 cites W2104635208 @default.
• W2058902845 cites W2112426918 @default.
• W2058902845 cites W2122355964 @default.
• W2058902845 cites W2128525457 @default.
• W2058902845 cites W2141807385 @default.
• W2058902845 cites W2157924726 @default.
• W2058902845 cites W2164700828 @default.
• W2058902845 cites W2169448433 @default.
• W2058902845 cites W2188385533 @default.
• W2058902845 doi "https://doi.org/10.1016/j.ejcb.2007.02.004" @default.
• W2058902845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17397964" @default.
• W2058902845 hasPublicationYear "2007" @default.
• W2058902845 type Work @default.
• W2058902845 sameAs 2058902845 @default.
• W2058902845 citedByCount "43" @default.
• W2058902845 countsByYear W20589028452012 @default.
• W2058902845 countsByYear W20589028452014 @default.
• W2058902845 countsByYear W20589028452015 @default.
• W2058902845 countsByYear W20589028452016 @default.
• W2058902845 countsByYear W20589028452017 @default.
• W2058902845 countsByYear W20589028452018 @default.
• W2058902845 countsByYear W20589028452019 @default.
• W2058902845 countsByYear W20589028452020 @default.
• W2058902845 countsByYear W20589028452021 @default.
• W2058902845 countsByYear W20589028452022 @default.
• W2058902845 crossrefType "journal-article" @default.
• W2058902845 hasAuthorship W2058902845A5002110691 @default.
• W2058902845 hasAuthorship W2058902845A5008405084 @default.
• W2058902845 hasAuthorship W2058902845A5027124617 @default.
• W2058902845 hasAuthorship W2058902845A5037306910 @default.
• W2058902845 hasAuthorship W2058902845A5038633678 @default.
• W2058902845 hasAuthorship W2058902845A5041640381 @default.
• W2058902845 hasAuthorship W2058902845A5044128159 @default.
• W2058902845 hasAuthorship W2058902845A5057176287 @default.
• W2058902845 hasAuthorship W2058902845A5089414900 @default.
• W2058902845 hasConcept C104317684 @default.
• W2058902845 hasConcept C107538193 @default.
• W2058902845 hasConcept C185592680 @default.
• W2058902845 hasConcept C20418707 @default.
• W2058902845 hasConcept C54355233 @default.
• W2058902845 hasConcept C71829478 @default.
• W2058902845 hasConcept C81241287 @default.
• W2058902845 hasConcept C86803240 @default.
• W2058902845 hasConcept C94435474 @default.
• W2058902845 hasConcept C95444343 @default.
• W2058902845 hasConceptScore W2058902845C104317684 @default.
• W2058902845 hasConceptScore W2058902845C107538193 @default.
• W2058902845 hasConceptScore W2058902845C185592680 @default.
• W2058902845 hasConceptScore W2058902845C20418707 @default.
• W2058902845 hasConceptScore W2058902845C54355233 @default.
• W2058902845 hasConceptScore W2058902845C71829478 @default.
• W2058902845 hasConceptScore W2058902845C81241287 @default.
• W2058902845 hasConceptScore W2058902845C86803240 @default.
• W2058902845 hasConceptScore W2058902845C94435474 @default.
• W2058902845 hasConceptScore W2058902845C95444343 @default.
• W2058902845 hasIssue "11-12" @default.
• W2058902845 hasLocation W20589028451 @default.
• W2058902845 hasLocation W20589028452 @default.
• W2058902845 hasOpenAccess W2058902845 @default.
• W2058902845 hasPrimaryLocation W20589028451 @default.
• W2058902845 hasRelatedWork W1588182076 @default.
• W2058902845 hasRelatedWork W2021069524 @default.
• W2058902845 hasRelatedWork W2034763038 @default.
• W2058902845 hasRelatedWork W2059656320 @default.

• next