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• W2058904495 abstract "The renal excretion of drugs is mainly controlled by three factors: glomerular filtration, tubular secretion and tubular reabsorption. Only relatively polar drugs are excreted in appreciable amounts by the kidneys. Factors affecting renal excretion of drugs include: kidney function, protein binding, urine pH and urine flow. Impaired renal function may lead to a clinically significant accumulation of drugs eliminated by the kidneys, if more than 50% of the dose is normally excreted unchanged in the urine and the renal function is less than 50% of the normal value. Successful removal of a drug by dialysis requires that it possesses a polar character, low protein binding and a small to moderate volume of distribution." @default.
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• W2058904495 date "1985-08-01" @default.
• W2058904495 modified "2023-09-30" @default.
• W2058904495 title "FACTORS CONTRIBUTING TO VARIABILITY IN DRUG PHARMACOKINETICS. IV. RENAL EXCRETION" @default.
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• W2058904495 doi "https://doi.org/10.1111/j.1365-2710.1985.tb00932.x" @default.
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