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• W2058904561 abstract "Abstract The use of generic immunosuppressive agents is controversial, especially for the treatment of pediatric patients, as information on the bioavailability of generic immunosuppressants in children is particularly scarce. The aim of the study was to compare the bioavailabilities of two products containing mycophenolate mofetil, the innovator and a generic, in children. Pediatric patients with end‐stage renal disease on the waiting list for renal transplantation received a single oral dose of mycophenolate mofetil as either the innovator product (CellCept ® , Roche) or the generic (Tevacept ® , Teva Pharmaceuticals). A nine point pharmacokinetic profile was obtained. Mycophenolic acid concentration was quantitated in plasma by HPLC , plasma concentration‐against‐time curves were constructed, and bioavailability parameters were determined. Pharmaceutical quality analysis of both formulations, including drug content and dissolution profile, was also performed. There were no statistically significant differences between formulations in bioavailability parameters. Interindividual variability was very important, but individual values of AUC, an indicator of the extent of drug absorption, were within the same range for both formulations. The two formulations exhibited similar drug content and dissolution profiles, as well as comparable mycophenolic acid plasma levels in an end‐stage renal failure population." @default.
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• W2058904561 date "2014-06-30" @default.
• W2058904561 modified "2023-09-30" @default.
• W2058904561 title "Bioavailability of a generic of the immunosuppressive agent mycophenolate mofetil in pediatric patients" @default.
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• W2058904561 doi "https://doi.org/10.1111/petr.12311" @default.
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