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• W2058904591 abstract "<b><i>Background:</i></b> Alzheimer’s disease (AD) is a neurodegenerative disorder where β-amyloid tends to aggregate and form plaques. Lipid raft-associated ganglioside GM1 has been suggested to facilitate β-amyloid aggregation; furthermore, GM1 and GM2 are increased in lipid rafts isolated from cerebral cortex of AD cases. <b><i>Aim/Method:</i></b> The distribution of GM1 and GM2 was studied by immunohistochemistry in the frontal and temporal cortex of AD cases. Frontotemporal dementia (FTD) was included as a contrast group. <b><i>Results:</i></b> The distribution of GM1 and GM2 changes during the process of AD (n = 5) and FTD (n = 3) compared to controls (n = 5). Altered location of the GM1-positive small circular structures seems to be associated with myelin degradation. In the grey matter, the staining of GM1-positive plasma membranes might reflect neuronal loss in the AD/FTD tissue. The GM1-positive compact bundles were only visible in cells located in the AD frontal grey matter, possibly reflecting raft formation of GM1 and thus a pathological connection. Furthermore, our results suggest GM2 to be enriched within vesicles of pyramidal neurons of the AD/FTD brain. <b><i>Conclusion:</i></b> Our study supports the biochemical finding of ganglioside accumulation in cellular membranes of AD patients and shows a redistribution of these molecules." @default.
• W2058904591 created "2016-06-24" @default.
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• W2058904591 creator A5079499378 @default.
• W2058904591 creator A5091296158 @default.
• W2058904591 date "2012-01-01" @default.
• W2058904591 modified "2023-10-07" @default.
• W2058904591 title "Altered Distribution of the Gangliosides GM1 and GM2 in Alzheimer’s Disease" @default.
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• W2058904591 doi "https://doi.org/10.1159/000338181" @default.
• W2058904591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22572791" @default.
• W2058904591 hasPublicationYear "2012" @default.
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