FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058904843> ?p ?o ?g. }

• W2058904843 endingPage "147" @default.
• W2058904843 startingPage "137" @default.
• W2058904843 abstract "<i>Aims:</i> We address the question of the expression and the role of the growth hormone/insulin-like growth factor (GH/IGF) axis in the thymus. <i>Methods:</i> Using RT-qPCR, the expression profile of various components of the somatotrope GH/IGF axis was measured in different thymic cell types and during thymus embryogenesis in Balb/c mice. The effect of GH on T cell differentiation was explored via thymic organotypic culture. <i>Results:</i> Transcription of <i>Gh</i>, <i>Igf1</i>, <i>Igf2</i> and their related receptors predominantly occurred in thymic epithelial cells (TEC), while a low level of <i>Gh</i> and <i>Igf1r </i>transcription was also evidenced in thymic T cells (thymocytes). <i>Gh</i>, <i>Ghr</i>, <i>Ins2</i>, <i>Igf1</i>, <i>Igf2</i>, and <i>Igfr1</i> displayed distinct expression profiles depending on the developmental stage. The protein concentrations of IGF-1 and IGF-2 were in accordance with the profile of their gene expression. In fetal thymus organ cultures (FTOC) derived from Balb/c mice, treatment with exogenous GH resulted in a significant increase of double negative CD4–CD8– T cells and CD4+ T cells, together with a decrease in double positive CD4+CD8+ T cells. These changes were inhibited by concomitant treatment with GH and the GH receptor (GHR) antagonist pegvisomant. However, GH treatment also induced a significant decrease in FTOC <i>Gh</i>, <i>Ghr</i> and <i>Igf1</i> expression. <i>Conclusion:</i> These data show that the thymotropic properties of the somatotrope GH/IGF-1 axis involve an interaction between exogenous GH and GHR expressed by TEC. Since thymic IGF-1 is not increased by GH treatment, the effects of GH upon T cell differentiation could implicate a different local growth factor or cytokine." @default.
• W2058904843 created "2016-06-24" @default.
• W2058904843 creator A5008019167 @default.
• W2058904843 creator A5013398931 @default.
• W2058904843 creator A5013491594 @default.
• W2058904843 creator A5015139462 @default.
• W2058904843 creator A5015820857 @default.
• W2058904843 creator A5028863868 @default.
• W2058904843 creator A5044311121 @default.
• W2058904843 creator A5045248528 @default.
• W2058904843 creator A5050692336 @default.
• W2058904843 creator A5065067832 @default.
• W2058904843 creator A5077566468 @default.
• W2058904843 creator A5085258874 @default.
• W2058904843 date "2012-01-01" @default.
• W2058904843 modified "2023-10-03" @default.
• W2058904843 title "Expression of the Growth Hormone/Insulin-Like Growth Factor Axis during Balb/c Thymus Ontogeny and Effects of Growth Hormone upon ex vivo T Cell Differentiation" @default.
• W2058904843 cites W1498259953 @default.
• W2058904843 cites W1533833543 @default.
• W2058904843 cites W1831528718 @default.
• W2058904843 cites W1832351337 @default.
• W2058904843 cites W1970846510 @default.
• W2058904843 cites W1974823036 @default.
• W2058904843 cites W1977793060 @default.
• W2058904843 cites W1978185061 @default.
• W2058904843 cites W1978564100 @default.
• W2058904843 cites W1982816938 @default.
• W2058904843 cites W1986768602 @default.
• W2058904843 cites W1988608139 @default.
• W2058904843 cites W1990595839 @default.
• W2058904843 cites W1999801514 @default.
• W2058904843 cites W2001002654 @default.
• W2058904843 cites W2006865758 @default.
• W2058904843 cites W2009682935 @default.
• W2058904843 cites W2009928329 @default.
• W2058904843 cites W2012021007 @default.
• W2058904843 cites W2013882368 @default.
• W2058904843 cites W2019608635 @default.
• W2058904843 cites W2027465939 @default.
• W2058904843 cites W2036014639 @default.
• W2058904843 cites W2044063819 @default.
• W2058904843 cites W2044485781 @default.
• W2058904843 cites W2047293271 @default.
• W2058904843 cites W2049740824 @default.
• W2058904843 cites W2058465406 @default.
• W2058904843 cites W2073724618 @default.
• W2058904843 cites W2086240590 @default.
• W2058904843 cites W2090119151 @default.
• W2058904843 cites W2092799297 @default.
• W2058904843 cites W2095204375 @default.
• W2058904843 cites W2096992142 @default.
• W2058904843 cites W2098058605 @default.
• W2058904843 cites W2107277218 @default.
• W2058904843 cites W2113844040 @default.
• W2058904843 cites W2119950606 @default.
• W2058904843 cites W2126278946 @default.
• W2058904843 cites W2142337535 @default.
• W2058904843 cites W2164391396 @default.
• W2058904843 cites W4230074902 @default.
• W2058904843 cites W4233984730 @default.
• W2058904843 cites W4237361898 @default.
• W2058904843 cites W4238161974 @default.
• W2058904843 cites W4238927439 @default.
• W2058904843 cites W4247641001 @default.
• W2058904843 cites W4251056328 @default.
• W2058904843 cites W4252293896 @default.
• W2058904843 cites W4253124490 @default.
• W2058904843 cites W4254504920 @default.
• W2058904843 doi "https://doi.org/10.1159/000328844" @default.
• W2058904843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22261974" @default.
• W2058904843 hasPublicationYear "2012" @default.
• W2058904843 type Work @default.
• W2058904843 sameAs 2058904843 @default.
• W2058904843 citedByCount "21" @default.
• W2058904843 countsByYear W20589048432012 @default.
• W2058904843 countsByYear W20589048432013 @default.
• W2058904843 countsByYear W20589048432014 @default.
• W2058904843 countsByYear W20589048432015 @default.
• W2058904843 countsByYear W20589048432016 @default.
• W2058904843 countsByYear W20589048432017 @default.
• W2058904843 countsByYear W20589048432018 @default.
• W2058904843 countsByYear W20589048432019 @default.
• W2058904843 countsByYear W20589048432020 @default.
• W2058904843 countsByYear W20589048432021 @default.
• W2058904843 countsByYear W20589048432022 @default.
• W2058904843 countsByYear W20589048432023 @default.
• W2058904843 crossrefType "journal-article" @default.
• W2058904843 hasAuthorship W2058904843A5008019167 @default.
• W2058904843 hasAuthorship W2058904843A5013398931 @default.
• W2058904843 hasAuthorship W2058904843A5013491594 @default.
• W2058904843 hasAuthorship W2058904843A5015139462 @default.
• W2058904843 hasAuthorship W2058904843A5015820857 @default.
• W2058904843 hasAuthorship W2058904843A5028863868 @default.
• W2058904843 hasAuthorship W2058904843A5044311121 @default.
• W2058904843 hasAuthorship W2058904843A5045248528 @default.
• W2058904843 hasAuthorship W2058904843A5050692336 @default.
• W2058904843 hasAuthorship W2058904843A5065067832 @default.
• W2058904843 hasAuthorship W2058904843A5077566468 @default.

• next