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- W2058904982 abstract "Eukaryotic ribosomes are assembled in the nucleolus before export to the cytoplasm. Ribosome formation is a highly dynamic and coordinated multistep process, which requires synthesis, processing and modification of pre-rRNAs, assembly with ribosomal proteins and transient interaction of numerous non-ribosomal factors with the evolving pre-ribosomal particles. In the past two years, exciting insights into the sequential events occurring during pre-ribosome formation have been obtained, thanks largely to the advances in proteomic analyses. We now have a first biochemical map of the earliest 90S pre-ribosomes and of their daughter pre-40S and pre-60S ribosomal subunits along their path from the nucleolus to the cytoplasm. The future challenge will be to assign functions to the more than 150 non-ribosomal factors that transiently associate with the developing pre-ribosomes." @default.
- W2058904982 created "2016-06-24" @default.
- W2058904982 creator A5016051751 @default.
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- W2058904982 date "2003-05-01" @default.
- W2058904982 modified "2023-10-16" @default.
- W2058904982 title "Pre-ribosomes on the road from the nucleolus to the cytoplasm" @default.
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- W2058904982 doi "https://doi.org/10.1016/s0962-8924(03)00054-0" @default.
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