Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058906518> ?p ?o ?g. }
- W2058906518 endingPage "563" @default.
- W2058906518 startingPage "555" @default.
- W2058906518 abstract "Abstract The integrity of transplanted mesenchymal stem cells (MSCs) for cardiac regeneration is dependent on cell–cell or cell–matrix adhesion, which is inhibited by reactive oxygen species (ROS) generated in ischemic surroundings after myocardial infarction. Intracellular ROS play a key role in the regulation of cell adhesion, migration, and proliferation. This study was designed to investigate the role of ROS on MSC adhesion. In H2O2 treated MSCs, adhesion and spreading were inhibited and detachment was increased in a dose-dependent manner, and these effects were significantly rescued by co-treatment with the free radical scavenger, N-acetyl-L-cysteine (NAC, 1 mM). A similar pattern was observed on plates coated with different matrices such as fibronectin and cardiogel. Hydrogen peroxide treatment resulted in a marked decrease in the level of focal adhesion-related molecules, such as phospho-FAK and p-Src in MSCs. We also observed a significant decrease in the integrin-related adhesion molecules, αV and β1, in H2O2 treated MSCs. When injected into infarcted hearts, the adhesion of MSCs co-injected with NAC to the border region was significantly improved. Consequently, we observed that fibrosis and infarct size were reduced in MSC and NAC-injected rat hearts compared to in MSC-only injected hearts. These results indicate that ROS inhibit cellular adhesion of engrafted MSCs and provide evidence that the elimination of ROS might be a novel strategy for improving the survival of engrafted MSCs." @default.
- W2058906518 created "2016-06-24" @default.
- W2058906518 creator A5008336825 @default.
- W2058906518 creator A5008942832 @default.
- W2058906518 creator A5031142749 @default.
- W2058906518 creator A5037114832 @default.
- W2058906518 creator A5040269875 @default.
- W2058906518 creator A5042614500 @default.
- W2058906518 creator A5046397220 @default.
- W2058906518 creator A5057956173 @default.
- W2058906518 creator A5064440520 @default.
- W2058906518 creator A5072940961 @default.
- W2058906518 creator A5073470074 @default.
- W2058906518 creator A5088516552 @default.
- W2058906518 date "2010-01-13" @default.
- W2058906518 modified "2023-10-11" @default.
- W2058906518 title "Reactive Oxygen Species Inhibit Adhesion of Mesenchymal Stem Cells Implanted into Ischemic Myocardium via Interference of Focal Adhesion Complex" @default.
- W2058906518 cites W1631250427 @default.
- W2058906518 cites W1969095342 @default.
- W2058906518 cites W1972143467 @default.
- W2058906518 cites W1979108161 @default.
- W2058906518 cites W1982354058 @default.
- W2058906518 cites W1999750787 @default.
- W2058906518 cites W2001670129 @default.
- W2058906518 cites W2013471060 @default.
- W2058906518 cites W2020492688 @default.
- W2058906518 cites W2023677185 @default.
- W2058906518 cites W2026632078 @default.
- W2058906518 cites W2029231027 @default.
- W2058906518 cites W2036592479 @default.
- W2058906518 cites W2036806537 @default.
- W2058906518 cites W2037619760 @default.
- W2058906518 cites W2066305068 @default.
- W2058906518 cites W2075344844 @default.
- W2058906518 cites W2098234683 @default.
- W2058906518 cites W2099739903 @default.
- W2058906518 cites W2114705189 @default.
- W2058906518 cites W2115830594 @default.
- W2058906518 cites W2118161860 @default.
- W2058906518 cites W2121559647 @default.
- W2058906518 cites W2151722542 @default.
- W2058906518 cites W2153059526 @default.
- W2058906518 cites W2168918180 @default.
- W2058906518 cites W2346489503 @default.
- W2058906518 cites W4235478998 @default.
- W2058906518 doi "https://doi.org/10.1002/stem.302" @default.
- W2058906518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20073042" @default.
- W2058906518 hasPublicationYear "2010" @default.
- W2058906518 type Work @default.
- W2058906518 sameAs 2058906518 @default.
- W2058906518 citedByCount "194" @default.
- W2058906518 countsByYear W20589065182012 @default.
- W2058906518 countsByYear W20589065182013 @default.
- W2058906518 countsByYear W20589065182014 @default.
- W2058906518 countsByYear W20589065182015 @default.
- W2058906518 countsByYear W20589065182016 @default.
- W2058906518 countsByYear W20589065182017 @default.
- W2058906518 countsByYear W20589065182018 @default.
- W2058906518 countsByYear W20589065182019 @default.
- W2058906518 countsByYear W20589065182020 @default.
- W2058906518 countsByYear W20589065182021 @default.
- W2058906518 countsByYear W20589065182022 @default.
- W2058906518 countsByYear W20589065182023 @default.
- W2058906518 crossrefType "journal-article" @default.
- W2058906518 hasAuthorship W2058906518A5008336825 @default.
- W2058906518 hasAuthorship W2058906518A5008942832 @default.
- W2058906518 hasAuthorship W2058906518A5031142749 @default.
- W2058906518 hasAuthorship W2058906518A5037114832 @default.
- W2058906518 hasAuthorship W2058906518A5040269875 @default.
- W2058906518 hasAuthorship W2058906518A5042614500 @default.
- W2058906518 hasAuthorship W2058906518A5046397220 @default.
- W2058906518 hasAuthorship W2058906518A5057956173 @default.
- W2058906518 hasAuthorship W2058906518A5064440520 @default.
- W2058906518 hasAuthorship W2058906518A5072940961 @default.
- W2058906518 hasAuthorship W2058906518A5073470074 @default.
- W2058906518 hasAuthorship W2058906518A5088516552 @default.
- W2058906518 hasBestOaLocation W20589065181 @default.
- W2058906518 hasConcept C1491633281 @default.
- W2058906518 hasConcept C151166631 @default.
- W2058906518 hasConcept C16224149 @default.
- W2058906518 hasConcept C171056886 @default.
- W2058906518 hasConcept C178790620 @default.
- W2058906518 hasConcept C185592680 @default.
- W2058906518 hasConcept C189165786 @default.
- W2058906518 hasConcept C195687474 @default.
- W2058906518 hasConcept C198826908 @default.
- W2058906518 hasConcept C203014093 @default.
- W2058906518 hasConcept C28328180 @default.
- W2058906518 hasConcept C48349386 @default.
- W2058906518 hasConcept C55493867 @default.
- W2058906518 hasConcept C62478195 @default.
- W2058906518 hasConcept C84416704 @default.
- W2058906518 hasConcept C85789140 @default.
- W2058906518 hasConcept C86492073 @default.
- W2058906518 hasConcept C86803240 @default.
- W2058906518 hasConcept C95444343 @default.
- W2058906518 hasConceptScore W2058906518C1491633281 @default.
- W2058906518 hasConceptScore W2058906518C151166631 @default.