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- W2058909897 abstract "Abstract Treatment with heparin or preferential removal of lysine-rich histones (LRH) stimulates endogenous DNA polymerase and template activities in swine aortic nuclei. The activities can be further enhanced in the presence of an endonuclease like DNase I. In contrast, the extraction of LRH reversibly inhibits the poly(ADP-ribose) polymerase activity of the extracted nuclei. This is due to the removal of the enzyme along with the LRH and the addition of the extract to the extracted nuclei reverses this inhibition. Heparin, on the other hand, does not inhibit the poly(ADP-ribose) polymerase unless very high concentrations are used. It appears that the removal of LRH as well as poly(ADP-ribose) polymerase exposes initiation sites for DNA polymerase." @default.
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- W2058909897 date "1978-03-01" @default.
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- W2058909897 title "Effect of heparin or removal of lysine-rich histone fraction on the poly(ADP-ribose) polymerase, DNA polymerase and template activity of isolated swine aortic nuclei" @default.
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- W2058909897 doi "https://doi.org/10.1016/0014-4827(78)90217-3" @default.
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