FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058915511> ?p ?o ?g. }

• W2058915511 endingPage "73" @default.
• W2058915511 startingPage "64" @default.
• W2058915511 abstract "Injury to the donor heart during cold preservation has a negative impact on graft survival before transplantation. This study aims to examine whether doxycycline, known as an MMP-2 inhibitor, has a positive effect on donor heart preservation via its antioxidant action when added to standard preservation solution. Hearts were obtained from 3-month-old male Wistar rats and randomly divided into three groups: hearts stored for 1 h at 4 °C (1) with doxycycline preservation solution (DOX cardioplegia) with low Ca2+; (2) with standard cardioplegia with low Ca2+; and (3) unstored hearts. All hearts were perfused in working mode, arrested at 37 °C, removed from the perfusion system, reattached in Langendorff perfusion system, and converted to working mode for 1 h. At the end of the storage period, hearts preserved in DOX cardioplegia had significantly less weight gain than those preserved in the standard cardioplegia. DOX cardioplegia-induced preservation resulted in significantly higher heart rates and better recovery quality during reperfusion in aortic flow compared to the standard cardioplegia group. Recovery in the left ventricular function and Lambeth Convention Arrhythmia scores during 1 h reperfusion were also significantly better in the DOX cardioplegia group. Biochemical data showed that DOX cardioplegia prevented an increase in MMP-2 activity and blocked apoptosis through increased activity of the pro-survival kinase Akt in the donor heart homogenates. DOX cardioplegia also led to a balanced oxidant/antioxidant level in the heart homogenates. This is the first study to report that cardioplegia solution containing doxycycline provides better cardioprotection via the preservation of heart function, through its role in controlling cellular redox status during static cold storage." @default.
• W2058915511 created "2016-06-24" @default.
• W2058915511 creator A5019062339 @default.
• W2058915511 creator A5030178607 @default.
• W2058915511 creator A5054874015 @default.
• W2058915511 creator A5065266648 @default.
• W2058915511 creator A5066360294 @default.
• W2058915511 date "2013-10-09" @default.
• W2058915511 modified "2023-10-18" @default.
• W2058915511 title "Improvement of Functional Recovery of Donor Heart Following Cold Static Storage with Doxycycline Cardioplegia" @default.
• W2058915511 cites W1514649841 @default.
• W2058915511 cites W1971653265 @default.
• W2058915511 cites W1975290731 @default.
• W2058915511 cites W1982825862 @default.
• W2058915511 cites W1989271438 @default.
• W2058915511 cites W1990985580 @default.
• W2058915511 cites W2003222910 @default.
• W2058915511 cites W2011302251 @default.
• W2058915511 cites W2016248543 @default.
• W2058915511 cites W2018210869 @default.
• W2058915511 cites W2021582583 @default.
• W2058915511 cites W2025795193 @default.
• W2058915511 cites W2026800620 @default.
• W2058915511 cites W2027951376 @default.
• W2058915511 cites W2028513366 @default.
• W2058915511 cites W2029112282 @default.
• W2058915511 cites W2030717979 @default.
• W2058915511 cites W2041693042 @default.
• W2058915511 cites W2046029123 @default.
• W2058915511 cites W2048934888 @default.
• W2058915511 cites W2051711363 @default.
• W2058915511 cites W2054594640 @default.
• W2058915511 cites W2055485487 @default.
• W2058915511 cites W2068894422 @default.
• W2058915511 cites W2069563551 @default.
• W2058915511 cites W2083089504 @default.
• W2058915511 cites W2103396089 @default.
• W2058915511 cites W2104109951 @default.
• W2058915511 cites W2109771283 @default.
• W2058915511 cites W2111497869 @default.
• W2058915511 cites W2116682594 @default.
• W2058915511 cites W2117129841 @default.
• W2058915511 cites W2124032176 @default.
• W2058915511 cites W2127154601 @default.
• W2058915511 cites W2134039776 @default.
• W2058915511 cites W2136348600 @default.
• W2058915511 cites W2138759299 @default.
• W2058915511 cites W2144111134 @default.
• W2058915511 cites W2144324982 @default.
• W2058915511 cites W2154401382 @default.
• W2058915511 doi "https://doi.org/10.1007/s12012-013-9231-1" @default.
• W2058915511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3936127" @default.
• W2058915511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24104944" @default.
• W2058915511 hasPublicationYear "2013" @default.
• W2058915511 type Work @default.
• W2058915511 sameAs 2058915511 @default.
• W2058915511 citedByCount "14" @default.
• W2058915511 countsByYear W20589155112014 @default.
• W2058915511 countsByYear W20589155112015 @default.
• W2058915511 countsByYear W20589155112016 @default.
• W2058915511 countsByYear W20589155112017 @default.
• W2058915511 countsByYear W20589155112018 @default.
• W2058915511 countsByYear W20589155112019 @default.
• W2058915511 countsByYear W20589155112020 @default.
• W2058915511 countsByYear W20589155112022 @default.
• W2058915511 crossrefType "journal-article" @default.
• W2058915511 hasAuthorship W2058915511A5019062339 @default.
• W2058915511 hasAuthorship W2058915511A5030178607 @default.
• W2058915511 hasAuthorship W2058915511A5054874015 @default.
• W2058915511 hasAuthorship W2058915511A5065266648 @default.
• W2058915511 hasAuthorship W2058915511A5066360294 @default.
• W2058915511 hasBestOaLocation W20589155111 @default.
• W2058915511 hasConcept C113278225 @default.
• W2058915511 hasConcept C126322002 @default.
• W2058915511 hasConcept C146957229 @default.
• W2058915511 hasConcept C164705383 @default.
• W2058915511 hasConcept C185592680 @default.
• W2058915511 hasConcept C2777179404 @default.
• W2058915511 hasConcept C2778849806 @default.
• W2058915511 hasConcept C2779676291 @default.
• W2058915511 hasConcept C2911091166 @default.
• W2058915511 hasConcept C42219234 @default.
• W2058915511 hasConcept C500558357 @default.
• W2058915511 hasConcept C501593827 @default.
• W2058915511 hasConcept C55493867 @default.
• W2058915511 hasConcept C71924100 @default.
• W2058915511 hasConcept C98274493 @default.
• W2058915511 hasConceptScore W2058915511C113278225 @default.
• W2058915511 hasConceptScore W2058915511C126322002 @default.
• W2058915511 hasConceptScore W2058915511C146957229 @default.
• W2058915511 hasConceptScore W2058915511C164705383 @default.
• W2058915511 hasConceptScore W2058915511C185592680 @default.
• W2058915511 hasConceptScore W2058915511C2777179404 @default.
• W2058915511 hasConceptScore W2058915511C2778849806 @default.
• W2058915511 hasConceptScore W2058915511C2779676291 @default.
• W2058915511 hasConceptScore W2058915511C2911091166 @default.
• W2058915511 hasConceptScore W2058915511C42219234 @default.
• W2058915511 hasConceptScore W2058915511C500558357 @default.

• next