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- W2058948947 abstract "Estrogen receptor determination in metastatic breast cancer has been shown to be important in determining potential for response to endocrine therapy. One limitation to this procedure can be the availability of neoplastic material for receptor assay. This report describes patients in whom estrogen receptor status was determined using malignant cells obtained through routine posterior iliac crest bone marrow biopsy. The ability to obtain receptor data from percutaneous bone marrow biopsy specimens has proved to be of important in patients in whom other sites involved with tumor were not accessible.Because material for biopsy among breast cancer patients is often scarce, a new procedure using material obtained from percutaneous bone marrow biopsy was developed and is presented. Bone marrow biopsy was the source of neoplastic material in 42 patients and was used to determine whether percutaneous bone marrow biopsy specimens could provide the necessary neoplastic tissue for estrogen receptor (ER) determination. Of the 42 patients, specimens from 11 (26%) were found to have insufficient tumor material for further evaluation; of the remaining 31 patients, 12 (39%) contained quantitatively ( 7 fmol) or qualitatively significant estrogen binding. All 12 patients were treated with endocrine therapy alone. Of the 12 patients, 8 (67%) responded to hormonal manipulation. The majority of patients evaluated were without other measureable signs of recurrent disease. All data obtained served to corroborate the usefulness of routine percutaneous bone marrow specimen for receptor analysis. This use of bone marrow represents an important application of improved technology to clinical practice." @default.
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- W2058948947 date "1979-01-01" @default.
- W2058948947 modified "2023-10-16" @default.
- W2058948947 title "Estrogen receptor determination in percutaneous bone marrow biopsies of patients with metastatic breast cancer" @default.
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- W2058948947 doi "https://doi.org/10.1002/mpo.2950070314" @default.
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