FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058953608> ?p ?o ?g. }

• W2058953608 endingPage "2304" @default.
• W2058953608 startingPage "2301" @default.
• W2058953608 abstract "The distribution of a heavy metal binding protein, metallothionein, was studied immunocytochemically by using antimetallothionein antibody and the immunoperoxidase staining technique on histological sections of liver, kidney, intestine, lung, and testis from cadmium-treated rats. These tissues either accumulate heavy metals (e.g., liver, kidney, and testis) or are exposed to metal by ingestion or inhalation (intestine and lung). Staining for metallothionein was observed intracellularly in epithelial parenchymal cells of the liver and kidney; all hepatocytes and most renal tubular cells stained for the protein. Accumulation of metallothionein was not seen in connective tissue cells surrounding either blood vessels or renal tubules. Extracellular localization of metallothionein was also observed in the liver sinusoids and within the lumina of the renal tubules, suggesting a metal transport or excretory function for this protein. Surface columnar epithelial cells of the intestinal villi indicated the presence of metallothionein but connective tissue cells of the lamina propria were negative for the protein. The granular secretory Paneth cells of the small intestine also stained strongly for metallothionein as did respiratory epithelial cells of the lung. In the testis, metallothionein was detected in the Sertoli cells and interstitial cells but not within the spermatogonia. Sertoli cells are closely associated with the developing spermatogonia and appear to serve a nutritive role in spermatogenesis. Because of the secretory, absorptive, or nutritive function of the metallothionein-localizing cells in the organs studied, we suggest that metallothionein may be involved in metal storage or transport in addition to its commonly proposed detoxification role." @default.
• W2058953608 created "2016-06-24" @default.
• W2058953608 creator A5000308858 @default.
• W2058953608 creator A5002166337 @default.
• W2058953608 creator A5076569842 @default.
• W2058953608 date "1982-04-01" @default.
• W2058953608 modified "2023-10-16" @default.
• W2058953608 title "Immunochemical detection of metallothionein in specific epithelial cells of rat organs." @default.
• W2058953608 cites W1497254776 @default.
• W2058953608 cites W1503306791 @default.
• W2058953608 cites W1839823486 @default.
• W2058953608 cites W1976588543 @default.
• W2058953608 cites W1979017436 @default.
• W2058953608 cites W1979777689 @default.
• W2058953608 cites W1983667544 @default.
• W2058953608 cites W1986390199 @default.
• W2058953608 cites W2006793849 @default.
• W2058953608 cites W2012115931 @default.
• W2058953608 cites W2021629505 @default.
• W2058953608 cites W2073330838 @default.
• W2058953608 cites W2111179662 @default.
• W2058953608 cites W2170854359 @default.
• W2058953608 cites W2273389095 @default.
• W2058953608 cites W2321378101 @default.
• W2058953608 cites W2341188235 @default.
• W2058953608 doi "https://doi.org/10.1073/pnas.79.7.2301" @default.
• W2058953608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/346180" @default.
• W2058953608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7048317" @default.
• W2058953608 hasPublicationYear "1982" @default.
• W2058953608 type Work @default.
• W2058953608 sameAs 2058953608 @default.
• W2058953608 citedByCount "120" @default.
• W2058953608 countsByYear W20589536082013 @default.
• W2058953608 countsByYear W20589536082015 @default.
• W2058953608 countsByYear W20589536082016 @default.
• W2058953608 countsByYear W20589536082017 @default.
• W2058953608 countsByYear W20589536082018 @default.
• W2058953608 countsByYear W20589536082019 @default.
• W2058953608 countsByYear W20589536082021 @default.
• W2058953608 countsByYear W20589536082023 @default.
• W2058953608 crossrefType "journal-article" @default.
• W2058953608 hasAuthorship W2058953608A5000308858 @default.
• W2058953608 hasAuthorship W2058953608A5002166337 @default.
• W2058953608 hasAuthorship W2058953608A5076569842 @default.
• W2058953608 hasBestOaLocation W20589536081 @default.
• W2058953608 hasConcept C104317684 @default.
• W2058953608 hasConcept C123765429 @default.
• W2058953608 hasConcept C128102431 @default.
• W2058953608 hasConcept C134018914 @default.
• W2058953608 hasConcept C142724271 @default.
• W2058953608 hasConcept C159654299 @default.
• W2058953608 hasConcept C196822366 @default.
• W2058953608 hasConcept C203014093 @default.
• W2058953608 hasConcept C20719415 @default.
• W2058953608 hasConcept C2777310793 @default.
• W2058953608 hasConcept C2780091579 @default.
• W2058953608 hasConcept C2781068068 @default.
• W2058953608 hasConcept C28406088 @default.
• W2058953608 hasConcept C35866371 @default.
• W2058953608 hasConcept C518705261 @default.
• W2058953608 hasConcept C529295009 @default.
• W2058953608 hasConcept C542903549 @default.
• W2058953608 hasConcept C54355233 @default.
• W2058953608 hasConcept C55493867 @default.
• W2058953608 hasConcept C59822182 @default.
• W2058953608 hasConcept C71924100 @default.
• W2058953608 hasConcept C86803240 @default.
• W2058953608 hasConcept C95444343 @default.
• W2058953608 hasConceptScore W2058953608C104317684 @default.
• W2058953608 hasConceptScore W2058953608C123765429 @default.
• W2058953608 hasConceptScore W2058953608C128102431 @default.
• W2058953608 hasConceptScore W2058953608C134018914 @default.
• W2058953608 hasConceptScore W2058953608C142724271 @default.
• W2058953608 hasConceptScore W2058953608C159654299 @default.
• W2058953608 hasConceptScore W2058953608C196822366 @default.
• W2058953608 hasConceptScore W2058953608C203014093 @default.
• W2058953608 hasConceptScore W2058953608C20719415 @default.
• W2058953608 hasConceptScore W2058953608C2777310793 @default.
• W2058953608 hasConceptScore W2058953608C2780091579 @default.
• W2058953608 hasConceptScore W2058953608C2781068068 @default.
• W2058953608 hasConceptScore W2058953608C28406088 @default.
• W2058953608 hasConceptScore W2058953608C35866371 @default.
• W2058953608 hasConceptScore W2058953608C518705261 @default.
• W2058953608 hasConceptScore W2058953608C529295009 @default.
• W2058953608 hasConceptScore W2058953608C542903549 @default.
• W2058953608 hasConceptScore W2058953608C54355233 @default.
• W2058953608 hasConceptScore W2058953608C55493867 @default.
• W2058953608 hasConceptScore W2058953608C59822182 @default.
• W2058953608 hasConceptScore W2058953608C71924100 @default.
• W2058953608 hasConceptScore W2058953608C86803240 @default.
• W2058953608 hasConceptScore W2058953608C95444343 @default.
• W2058953608 hasIssue "7" @default.
• W2058953608 hasLocation W20589536081 @default.
• W2058953608 hasLocation W20589536082 @default.
• W2058953608 hasLocation W20589536083 @default.
• W2058953608 hasLocation W20589536084 @default.
• W2058953608 hasOpenAccess W2058953608 @default.
• W2058953608 hasPrimaryLocation W20589536081 @default.

• next