FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058960071> ?p ?o ?g. }

• W2058960071 endingPage "194" @default.
• W2058960071 startingPage "183" @default.
• W2058960071 abstract "Fumonisin B1 (FB1), a potent mycotoxin prevalent in corn and cereals, causes a variety of toxic effects in different mammalian species. The biochemical responses of FB1 involve inhibition of ceramide synthase leading to accumulation of free sphingoid bases and a possible involvement of tumor necrosis factor alpha (TNFalpha). To further characterize the role of TNFalpha, toxic response to FB1 was investigated in male C57BL/6J mice (WT) and a corresponding TNFalpha receptor knockout (TRK) strain, genetically modified to lack the TNFalpha1b receptor. The hepatotoxic effects of 5 daily injections of 2.25 mg/kg per day of FB1 were observed in WT but were reduced in TRK, evidenced by circulating alanine aminotransferase and aspartate aminotransferase levels and histopathological evaluation of the tissue. FB1 induced TNFalpha expression in the livers of both WT and TRK mice to a similar extent (3-4 fold over control); however, a corresponding increase of cellular NFkappaB, expected after the downstream cellular signaling of TNFalpha, was noted only in the WT. Accumulation of liver sphingosine after FB1 treatment was similar in both WT and TRK, but the FB1-induced increases in liver sphinganine and kidney sphingosine and sphinganine were lower in TRK than in WT. Results emphasized the role of TNFalpha in FB1-induced hepatotoxicity in mice and the possible relationship of sphingoid base accumulation and TNFalpha induction. Moreover, the presence of TNFalpha receptor 1b appears to be important in mediating the hepatotoxic responses of TNFalpha and FB1 in mice." @default.
• W2058960071 created "2016-06-24" @default.
• W2058960071 creator A5001090733 @default.
• W2058960071 creator A5009450265 @default.
• W2058960071 creator A5025106993 @default.
• W2058960071 creator A5060455958 @default.
• W2058960071 creator A5072080183 @default.
• W2058960071 date "2000-02-01" @default.
• W2058960071 modified "2023-09-24" @default.
• W2058960071 title "Tolerance to fumonisin toxicity in a mouse strain lacking the P75 tumor necrosis factor receptor" @default.
• W2058960071 cites W1964830665 @default.
• W2058960071 cites W1964967794 @default.
• W2058960071 cites W1965072263 @default.
• W2058960071 cites W1972302176 @default.
• W2058960071 cites W1974069634 @default.
• W2058960071 cites W1979595147 @default.
• W2058960071 cites W1983376060 @default.
• W2058960071 cites W1992615534 @default.
• W2058960071 cites W1995038174 @default.
• W2058960071 cites W1996381213 @default.
• W2058960071 cites W1997254493 @default.
• W2058960071 cites W2000051862 @default.
• W2058960071 cites W2008860913 @default.
• W2058960071 cites W2013282373 @default.
• W2058960071 cites W2017769599 @default.
• W2058960071 cites W2022247016 @default.
• W2058960071 cites W2023687907 @default.
• W2058960071 cites W2028297201 @default.
• W2058960071 cites W2035735208 @default.
• W2058960071 cites W2040913902 @default.
• W2058960071 cites W2042200680 @default.
• W2058960071 cites W2042223647 @default.
• W2058960071 cites W2042274679 @default.
• W2058960071 cites W2047725813 @default.
• W2058960071 cites W2050828232 @default.
• W2058960071 cites W2052829770 @default.
• W2058960071 cites W2053447158 @default.
• W2058960071 cites W2056266829 @default.
• W2058960071 cites W2065725081 @default.
• W2058960071 cites W2070038809 @default.
• W2058960071 cites W2090439142 @default.
• W2058960071 cites W2117873131 @default.
• W2058960071 cites W2161788277 @default.
• W2058960071 cites W2177328369 @default.
• W2058960071 cites W4254682918 @default.
• W2058960071 cites W4313379463 @default.
• W2058960071 doi "https://doi.org/10.1016/s0300-483x(99)00168-7" @default.
• W2058960071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10755704" @default.
• W2058960071 hasPublicationYear "2000" @default.
• W2058960071 type Work @default.
• W2058960071 sameAs 2058960071 @default.
• W2058960071 citedByCount "50" @default.
• W2058960071 countsByYear W20589600712018 @default.
• W2058960071 countsByYear W20589600712019 @default.
• W2058960071 countsByYear W20589600712020 @default.
• W2058960071 countsByYear W20589600712021 @default.
• W2058960071 countsByYear W20589600712022 @default.
• W2058960071 crossrefType "journal-article" @default.
• W2058960071 hasAuthorship W2058960071A5001090733 @default.
• W2058960071 hasAuthorship W2058960071A5009450265 @default.
• W2058960071 hasAuthorship W2058960071A5025106993 @default.
• W2058960071 hasAuthorship W2058960071A5060455958 @default.
• W2058960071 hasAuthorship W2058960071A5072080183 @default.
• W2058960071 hasConcept C126322002 @default.
• W2058960071 hasConcept C134018914 @default.
• W2058960071 hasConcept C134139212 @default.
• W2058960071 hasConcept C170493617 @default.
• W2058960071 hasConcept C17991360 @default.
• W2058960071 hasConcept C185592680 @default.
• W2058960071 hasConcept C190283241 @default.
• W2058960071 hasConcept C2777851122 @default.
• W2058960071 hasConcept C2778703144 @default.
• W2058960071 hasConcept C2779237115 @default.
• W2058960071 hasConcept C2781429003 @default.
• W2058960071 hasConcept C29730261 @default.
• W2058960071 hasConcept C55493867 @default.
• W2058960071 hasConcept C59822182 @default.
• W2058960071 hasConcept C61705674 @default.
• W2058960071 hasConcept C71924100 @default.
• W2058960071 hasConcept C84699730 @default.
• W2058960071 hasConcept C86803240 @default.
• W2058960071 hasConcept C92020748 @default.
• W2058960071 hasConcept C98274493 @default.
• W2058960071 hasConceptScore W2058960071C126322002 @default.
• W2058960071 hasConceptScore W2058960071C134018914 @default.
• W2058960071 hasConceptScore W2058960071C134139212 @default.
• W2058960071 hasConceptScore W2058960071C170493617 @default.
• W2058960071 hasConceptScore W2058960071C17991360 @default.
• W2058960071 hasConceptScore W2058960071C185592680 @default.
• W2058960071 hasConceptScore W2058960071C190283241 @default.
• W2058960071 hasConceptScore W2058960071C2777851122 @default.
• W2058960071 hasConceptScore W2058960071C2778703144 @default.
• W2058960071 hasConceptScore W2058960071C2779237115 @default.
• W2058960071 hasConceptScore W2058960071C2781429003 @default.
• W2058960071 hasConceptScore W2058960071C29730261 @default.
• W2058960071 hasConceptScore W2058960071C55493867 @default.
• W2058960071 hasConceptScore W2058960071C59822182 @default.
• W2058960071 hasConceptScore W2058960071C61705674 @default.

• next