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- W2058966042 abstract "SUMMARY 1. Intravenous or central treatment of spontaneously hypertensive rats (SHR) with the dopamine D 2 receptor agonist quinpirole caused a short‐lasting pressor response with little effect on heart rate. 2. At 30 min after intravenous administration of quinpirole, the antihypertensive effect of rilmenidine was significantly inhibited. This interaction of quinpirole and rilmenidine was similarly observed when quinpirole was administered either intravenously (0.3 or 0.1 mg/kg), in the lateral cerebral ventricles (0.1 mg/kg) or intracisternally (0.1 mg/kg) or when rilmenidine was administered intravenously (1 mg/kg) or intracisternally (0.1 mg/kg). 3. The apparent desensitization to the antihypertensive effect of rilmenidine 30 min after pretreatment with quinpirole was not observed after a 4 or 24 h interval. 4. These data suggest that quinpirole has prolonged effects on central sympathetic vasomotor mechanisms that are the target of centrally acting antihypertensive drugs. These and previous results show a functional interaction between central dopamine D 2 receptor activation and sympathetic responses mediated by a wide range of different receptors, including imidazoline and 5‐hydroxytryptamine 5‐HT 1A ‐receptors and (α‐adrenoceptors." @default.
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- W2058966042 date "1997-10-01" @default.
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- W2058966042 title "PRETREATMENT WITH THE DOPAMINE AGONIST QUINPIROLE INHIBITS CENTRAL ANTIHYPERTENSIVE MECHANISMS IN RATS*" @default.
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- W2058966042 doi "https://doi.org/10.1111/j.1440-1681.1997.tb02109.x" @default.
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