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- W2058969944 abstract "Ovarian cancer (OC) is a major cancer-related mortality among women. Recent studies suggest that many microRNAs (miRNAs) were dysregulated and involved in tumorigenesis of OC. The present study investigated the role of miR-25 in the development and progression of OC. The expression of miR-25 was increased in OC tissues and cell lines. Inhibition of miR-25 remarkably suppressed proliferation, migration, and invasion of OC cells. Large tumor suppressor 2 (LATS2), a tumor suppressor, was confirmed to be a direct target of miR-25 in OC cells. Moreover, restoration of LATS2 significantly attenuated the oncogenic effects of miR-25. Together, our data suggest an oncogenic role of miR-25 in OC and a potentially novel diagnostic and therapeutic target for OC treatment." @default.
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- W2058969944 date "2014-09-02" @default.
- W2058969944 modified "2023-09-24" @default.
- W2058969944 title "MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2" @default.
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- W2058969944 doi "https://doi.org/10.1007/s13277-014-2546-0" @default.
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