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- W2058982020 abstract "The metabolism of chemical carcinogens has been studied in cultured human bronchus, colon, duodenum, pancreatic duct, and esophagus. Metabolite patterns and carcinogen-DNA adducts are generally qualitatively similar among animal species, individuals within a species, and tissues within an individual. However, wide quantitative differences are observed between individuals in outbred animal species, including humans. These interindividual differences in amounts of carcinogen-DNA adducts and in activities of enzymes that are important in the metabolism of chemical carcinogens are similar in magnitude (10-to 150-fold) to those observed in pharmacogenetic studies of drug metabolism. The role of these differences as risk factors in human cancer is being investigated." @default.
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- W2058982020 date "1982-01-01" @default.
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- W2058982020 title "Differences in Metabolism of Chemical Carcinogens in Cultured Human Epithelial Tissues and Cells" @default.
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- W2058982020 doi "https://doi.org/10.1002/jcb.1982.240180304" @default.
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