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• W2058989036 abstract "In vitro evolution of synthetic polymers has been limited by a lack of methods for translating genetic information into synthetic libraries and for amplifying selected molecules. An in vitro selection system for peptide nucleic acids (PNA) now brings the evolution of functional PNA polymers within reach. Methods to evolve synthetic, rather than biological, polymers could significantly expand the functional potential of polymers that emerge from in vitro evolution. Requirements for synthetic polymer evolution include (i) sequence-specific polymerization of synthetic building blocks on an amplifiable template, (ii) display of the newly translated polymer strand in a manner that allows it to adopt folded structures, (iii) selection of synthetic polymer libraries for desired binding or catalytic properties and (iv) amplification of template sequences that survive selection in a manner that allows subsequent translation. Here we report the development of such a system for peptide nucleic acids (PNAs) using a set of 12 PNA pentamer building blocks. We validated the system by performing six iterated cycles of translation, selection and amplification on a library of 4.3 × 108 PNA-encoding DNA templates and observed >1,000,000-fold overall enrichment of a template encoding a biotinylated (streptavidin-binding) PNA. These results collectively provide an experimental foundation for PNA evolution in the laboratory." @default.
• W2058989036 created "2016-06-24" @default.
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• W2058989036 date "2009-12-27" @default.
• W2058989036 modified "2023-10-18" @default.
• W2058989036 title "An in vitro translation, selection and amplification system for peptide nucleic acids" @default.
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• W2058989036 doi "https://doi.org/10.1038/nchembio.280" @default.
• W2058989036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2808706" @default.
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• W2058989036 hasPublicationYear "2009" @default.
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