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• W2058990911 startingPage "8048" @default.
• W2058990911 abstract "The tuberous sclerosis complex-mammalian target of rapamycin (TSC-mTOR) cascade integrates growth factor and nutritional signals to regulate the synthesis of specific proteins. Because both growth factor signaling and glucose have been implicated in memory formation, we questioned whether mTOR activity is required for long-term spatial memory formation and whether this cascade is involved in the memory-augmenting effect of centrally applied glucose. To test our hypothesis, we directly administered rapamycin (an inhibitor of mTOR), glucose, 5-aminoimidazole-4-carboxamide-1beta-4-ribonucleoside (AICAR; an activator of AMP kinase), or glucose plus rapamycin into the dorsal hippocampus after we trained rats in the Morris water maze task. The results from these studies indicate that glucose enhances, whereas AICAR and rapamycin both impair, long-term spatial memory. Furthermore, the memory-impairing effect of targeted rapamycin administration could not be overcome by coadministration of glucose. Consistent with these behavioral results, biochemical analysis revealed that glucose and AICAR had opposing influences on the activation of the TSC-mTOR cascade, as indicated by the phosphorylation of ribosomal S6 kinase (S6K) and 4E binding protein 1 (4EBP1), targets of mTOR. Together, these findings suggest that memory formation requires the mTOR cascade and that the memory-enhancing effect of glucose involves its ability to activate this pathway." @default.
• W2058990911 created "2016-06-24" @default.
• W2058990911 creator A5010631994 @default.
• W2058990911 creator A5063633345 @default.
• W2058990911 creator A5087765123 @default.
• W2058990911 date "2006-08-02" @default.
• W2058990911 modified "2023-10-14" @default.
• W2058990911 title "Spatial Memory Formation and Memory-Enhancing Effect of Glucose Involves Activation of the Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway" @default.
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• W2058990911 doi "https://doi.org/10.1523/jneurosci.0671-06.2006" @default.
• W2058990911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673778" @default.
• W2058990911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16885218" @default.
• W2058990911 hasPublicationYear "2006" @default.
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