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- W2058991010 abstract "Synthesis of (—)‐(Acetoxymethyl)(hydroxymethyl)methyl(phenyl)germane [(—)‐MePhGe(CH 2 OAc)(CH 2 OH)] by an Esterase‐Catalyzed Transesterification: the First Enzymatic Synthesis of an Optically Active Germane The prochiral germane MePhGe(CH 2 OH) 2 ( 1 ) was synthesized by a six‐step synthesis starting from GeCl 4 ( 3 ) [ 3 → Cl 2 Ge(CH 2 Cl) 2 ( 4 ) → Ph 2 Ge(CH 2 Cl) 2 ( 5 ) → (CF 3 S(O) 2 O)PhGe(CH 2 Cl) 2 ( 6 ) → MePhGe(CH 2 Cl) 2 ( 7 ) → MePhGe(CH 2 OAc) 2 ( 8 ) → 1 ]. Reaction of 1 with Ac 2 O/NEt 3 (molar ratio 1 : Ac 2 O = 1:1) gave the racemic germane rac ‐MePhGe(CH 2 OAc)(CH 2 OH) ( rac ‐ 2 ). Stereoselective transesterification of 1 with vinyl acetate (acetate source and solvent), catalyzed by immobilized porcine liver esterase (PLE; E.C.‐3.1.1.1), yielded the optically active germane (—)‐MePhGe(CH 2 OAc)(CH 2 OH) [(—)‐ 2 ] (yield 57%, enantiomeric purity 50% ee)." @default.
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- W2058991010 title "Synthese von (—)‐(Acetoxymethyl)(hydroxymethyl)methyl(phenyl)german [(—)‐MePhGe(CH <sub>2</sub> OAc)(CH <sub>2</sub> OH)] durch eine Esterase‐katalysierte Umesterung: Die erste enzymatische Synthese eines optisch aktiven Germans" @default.
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- W2058991010 doi "https://doi.org/10.1002/cber.19941270409" @default.
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