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- W2058992051 abstract "Cell shape changes require the coordination of actin and microtubule cytoskeletons. The molecular mechanisms by which such coordination is achieved remain obscure, particularly in the context of epithelial cells within developing vertebrate embryos. We have identified a novel role for the actin-binding protein Shroom3 as a regulator of the microtubule cytoskeleton during epithelial morphogenesis. We show that Shroom3 is sufficient and also necessary to induce a redistribution of the microtubule regulatorγ-tubulin. Moreover, this change in γ-tubulin distribution underlies the assembly of aligned arrays of microtubules that drive apicobasal cell elongation. Finally, experiments with the related protein, Shroom1,demonstrate that γ-tubulin regulation is a conserved feature of this protein family. Together, the data demonstrate that Shroom family proteins govern epithelial cell behaviors by coordinating the assembly of both microtubule and actin cytoskeletons." @default.
- W2058992051 created "2016-06-24" @default.
- W2058992051 creator A5035520434 @default.
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- W2058992051 date "2007-04-01" @default.
- W2058992051 modified "2023-09-25" @default.
- W2058992051 title "Shroom family proteins regulate γ-tubulin distribution and microtubule architecture during epithelial cell shape change" @default.
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- W2058992051 doi "https://doi.org/10.1242/dev.02828" @default.
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