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• W2058993491 abstract "We examined the relation between cutaneous melanoma risk and the intercellular adhesion molecule-1 (ICAM-1) gene single nucleotide polymorphisms G241R and K469E, as well as the circulating soluble form of ICAM-1 determined in plasma, in the population of Modena Province, northern Italy. Individuals carrying at least one R241 allele, versus those carrying the wild-type GG genotype, had a relative risk of melanoma of 4.3 (P=0.022), whereas the K469E polymorphism was unrelated to disease risk. Soluble ICAM-1 levels above 10 ng/ml directly and strongly correlated with melanoma risk. In this population, individuals carrying the R241 allele of the ICAM-1 gene appeared to show an enhanced susceptibility to cutaneous melanoma, possibly because of increased ICAM-1 expression." @default.
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• W2058993491 date "2006-02-01" @default.
• W2058993491 modified "2023-09-23" @default.
• W2058993491 title "High risk of cutaneous melanoma amongst carriers of the intercellular adhesion molecule-1 R241 allele" @default.
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• W2058993491 doi "https://doi.org/10.1097/01.cmr.0000198450.19204.dd" @default.
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