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• W2058993634 abstract "► Marine biotechnology has matured into a sector delivering useful drugs based on marine chemistry following a thirty-year period of development. ► This success is built upon the incredible diversity of the marine habitat. ► Marine organisms have provided the molecular tools to drive analytical biotechnology from thermostable polymerases to new fluorescent protein markers. ► The next generation of analytical methods will be those methods that provide biochemical and physiological information to enhance and extract meaning from the current glut of difficult to interpret sequence data. Marine biotechnology is the industrial, medical or environmental application of biological resources from the sea. Since the marine environment is the most biologically and chemically diverse habitat on the planet, marine biotechnology has, in recent years delivered a growing number of major therapeutic products, industrial and environmental applications and analytical tools. These range from the use of a snail toxin to develop a pain control drug, metabolites from a sea squirt to develop an anti-cancer therapeutic, and marine enzymes to remove bacterial biofilms. In addition, well known and broadly used analytical techniques are derived from marine molecules or enzymes, including green fluorescence protein gene tagging methods and heat resistant polymerases used in the polymerase chain reaction. Advances in bacterial identification, metabolic profiling and physical handling of cells are being revolutionised by techniques such as mass spectrometric analysis of bacterial proteins. Advances in instrumentation and a combination of these physical advances with progress in proteomics and bioinformatics are accelerating our ability to harness biology for commercial gain. Single cell Raman spectroscopy and microfluidics are two emerging techniques which are also discussed elsewhere in this issue. In this review, we provide a brief survey and update of the most powerful and rapidly growing analytical techniques as used in marine biotechnology, together with some promising examples of less well known earlier stage methods which may make a bigger impact in the future." @default.
• W2058993634 created "2016-06-24" @default.
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• W2058993634 date "2012-02-01" @default.
• W2058993634 modified "2023-09-29" @default.
• W2058993634 title "New and emerging analytical techniques for marine biotechnology" @default.
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• W2058993634 doi "https://doi.org/10.1016/j.copbio.2011.12.007" @default.
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