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- W2058996880 abstract "The in vivo effect of tissue kallikrein on the mucociliary activity in the rabbit maxillary sinus was investigated administering the substance (0.1–5 mU/kg) via a. maxillaris and recording the response with a non-invasive photoelectric technique. Tissue kallikrein accelerated mucociliary activity, with a maximum response for the dose 5 mU/kg (33.7 ± 13.4 % from basal levels, n = 5). The effect had a latency of abut 1 min, with a peak within 2–3 min after the beginning of the administration. The response to tissue kallikrein displayed tachyphylaxis with a second dose producing a weaker response. Pretreatment with the protease inhibitor aprotinin (10000 KIU bolus/kg) inhibited the action of tissue kallikrein. Tissue kallikrein probably stimulates mucociliary activity by producing lysylbradykinin from kininogen. Bradykinin has in an earlier study been shown to stimulate mucociliary activity." @default.
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- W2058996880 date "1991-01-01" @default.
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- W2058996880 title "Tissue Kallikrein Stimulates Mucociliary Activity in the Rabbit Maxillary Sinus" @default.
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- W2058996880 doi "https://doi.org/10.3109/00016489109100767" @default.
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