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• W2059002017 abstract "Hairy cell leukemia (HCL), a rare haematological disorder of B-cell origin, mainly presents with bone marrow infiltration, haematopoietic insufficiency, and splenomegaly. In some cases, osteolytic lesions can be observed. Many of these clinical features, especially haematopoietic insufficiency and osteolytic lesions are likely to be caused by soluble factors, such as cytokines. There is evidence that these factors are produced by the malignant hairy cells themselves, suggesting a paracrine pathway. The importance of autocrine as well as paracrine growth loops in growth regulation of HCL-cells is supported by a series of excellent studies, performed within the last few years. It could be clearly shown that cytokines are involved in this autocrine and paracrine regulatory process. The most important cytokines which should be mentioned in this respect are tumor necrosis factor alpha, (TNF alpha). Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-6 (IL-6) and B-cell-growth factor (BCGF). The role of other factors such as viruses and oncogenes remains rather unclear. Nevertheless, recent data suggest that the c-fms, which encodes for the macrophage colony stimulating factor (M-CSF) may be involved in the pathophysiological control of HCL growth. In this review, we summarise the important data and studies performed recently which shed light on the complex network of autocrine and paracrine growth regulation of HCL." @default.
• W2059002017 created "2016-06-24" @default.
• W2059002017 creator A5017798149 @default.
• W2059002017 creator A5018920707 @default.
• W2059002017 date "1995-05-01" @default.
• W2059002017 modified "2023-09-26" @default.
• W2059002017 title "Autocrine and Paracrine Regulation of Neoplastic Cell Growth in Hairy Cell Leukemia" @default.
• W2059002017 cites W1210631084 @default.
• W2059002017 cites W1230128150 @default.
• W2059002017 cites W1271773534 @default.
• W2059002017 cites W1489856963 @default.
• W2059002017 cites W1499656911 @default.
• W2059002017 cites W1536347913 @default.
• W2059002017 cites W1536596922 @default.
• W2059002017 cites W1552669957 @default.
• W2059002017 cites W1558416642 @default.
• W2059002017 cites W158093869 @default.
• W2059002017 cites W1582355242 @default.
• W2059002017 cites W1606244779 @default.
• W2059002017 cites W1607189552 @default.
• W2059002017 cites W1607578883 @default.
• W2059002017 cites W1656306389 @default.
• W2059002017 cites W1660008514 @default.
• W2059002017 cites W173783495 @default.
• W2059002017 cites W187104951 @default.
• W2059002017 cites W1891016071 @default.
• W2059002017 cites W1964264035 @default.
• W2059002017 cites W1964846497 @default.
• W2059002017 cites W1971786640 @default.
• W2059002017 cites W1980103773 @default.
• W2059002017 cites W1984893824 @default.
• W2059002017 cites W1992401642 @default.
• W2059002017 cites W1995628336 @default.
• W2059002017 cites W1999197294 @default.
• W2059002017 cites W1999624072 @default.
• W2059002017 cites W2002076761 @default.
• W2059002017 cites W2013241306 @default.
• W2059002017 cites W2017457313 @default.
• W2059002017 cites W2019436590 @default.
• W2059002017 cites W2019821332 @default.
• W2059002017 cites W2021843868 @default.
• W2059002017 cites W2025596021 @default.
• W2059002017 cites W2043938684 @default.
• W2059002017 cites W2044495978 @default.
• W2059002017 cites W2047738701 @default.
• W2059002017 cites W2048325240 @default.
• W2059002017 cites W2050256776 @default.
• W2059002017 cites W2050877178 @default.
• W2059002017 cites W2052717160 @default.
• W2059002017 cites W2055882495 @default.
• W2059002017 cites W2057123987 @default.
• W2059002017 cites W2057409901 @default.
• W2059002017 cites W2062925771 @default.
• W2059002017 cites W2063462125 @default.
• W2059002017 cites W2064632541 @default.
• W2059002017 cites W2067475593 @default.
• W2059002017 cites W2068103783 @default.
• W2059002017 cites W2070622761 @default.
• W2059002017 cites W2070862685 @default.
• W2059002017 cites W2074457690 @default.
• W2059002017 cites W2075774111 @default.
• W2059002017 cites W2078917040 @default.
• W2059002017 cites W2088133130 @default.
• W2059002017 cites W2089298737 @default.
• W2059002017 cites W2092252914 @default.
• W2059002017 cites W2095343750 @default.
• W2059002017 cites W2111557655 @default.
• W2059002017 cites W2115940622 @default.
• W2059002017 cites W2116656764 @default.
• W2059002017 cites W2123733931 @default.
• W2059002017 cites W2125753847 @default.
• W2059002017 cites W2128232665 @default.
• W2059002017 cites W2132840037 @default.
• W2059002017 cites W2138424708 @default.
• W2059002017 cites W2139532093 @default.
• W2059002017 cites W2140098325 @default.
• W2059002017 cites W2141001643 @default.
• W2059002017 cites W2144144073 @default.
• W2059002017 cites W215066553 @default.
• W2059002017 cites W2150988478 @default.
• W2059002017 cites W2152553808 @default.
• W2059002017 cites W2156216301 @default.
• W2059002017 cites W2157839847 @default.
• W2059002017 cites W2165644577 @default.
• W2059002017 cites W2168103204 @default.
• W2059002017 cites W2168822788 @default.
• W2059002017 cites W2173616717 @default.
• W2059002017 cites W2182204751 @default.
• W2059002017 cites W2318643269 @default.
• W2059002017 cites W2337870036 @default.
• W2059002017 cites W2399967710 @default.
• W2059002017 cites W2402421550 @default.
• W2059002017 cites W2408309479 @default.
• W2059002017 cites W2409839901 @default.
• W2059002017 cites W2410057670 @default.
• W2059002017 cites W2410946777 @default.
• W2059002017 cites W2411121655 @default.
• W2059002017 cites W2411404726 @default.
• W2059002017 cites W2411413141 @default.
• W2059002017 cites W2412370499 @default.

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