FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059008055> ?p ?o ?g. }

• W2059008055 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILIntroduction: Inflammation is regulated through a balance between pro-inflammatory and anti-inflammatory cytokines. Tumor necrosis factor (TNF), a pro-inflammatory cytokine, is a central mediator of inflammation and is involved in both cancer development and progression. The TNF family inhibits tumorigenesis via apoptosis, but deregulation of TNFs promotes tumor cell tissue invasion, migration, and metastasis. Germline variations in TNF-related genes may influence expression levels and thus influence lung cancer prognosis. We tested this hypothesis in a large series of non-small cell lung cancer patients (NSCLC) treated at the Moffitt Cancer Center. Methods: Using the Illumina GoldenGate Assay we genotyped 305 SNPs from 53 different inflammation-related genes in 651 NSCLC patients. Using multivariable Cox proportional hazard regression all SNPs were analyzed by an additive model for overall survival and were ranked by P-value. Correction for multiple comparisons, haplotype, and stratified analyses were also performed. Results: The overall median survival time was 25 months. Fourteen of the inflammation-related SNPs were significantly associated with NSCLC survival and 4 of the fourteen were located in the TNF-receptor superfamily member 10b gene. The linkage disequilibrium map for the 4 loci revealed r^2 values ranging from 0.36 to 0.66. When compared to the C/C genotype, the T-allele genotypes of the top ranked SNP (TNFRSF10B:rs11785599) were associated with a 41% increased risk of death (95% CI 1.16-1.70) after adjusting for age, gender, smoking, histology, stage, and first course treatment. The risk genotypes for the other three statistically significant TNF loci (rs1047275, rs4460370, and rs883429) exhibited a 35% (95% CI 1.11-1.65), 29% (95% CI 1.06-1.57), and 23% (95% CI 1.00-1.53) increased risk of death, respectively. Haplotype analyses of all four loci revealed that the risk haplotype (TCTT) was associated with a 77% increased risk of death (95% CI 1.25-2.52) when compared to the referent wildtype haplotype (CGCC). Stratified analyses demonstrated that the top ranked SNP (rs11785599) remained significantly associated with survival for both: men and women, early (I + II) and late stage patients (III + IV), and adenocarcinoma and squamous cell carcinoma tumors. When the data were analyzed by chemotherapy regimen, the risk genotypes of rs11785599 were consistently associated with an increased risk of death but the only significant finding was among patients treated with platinum agents plus taxanes (HR = 1.81; 95% CI 1.29-2.52). Conclusions: Although the functional significance of this SNP needs to be elucidated, these data suggest a possible role of TNFRSF10B:rs11785599 in the prognosis of NSCLC. If validated, these data have potential translational implications by optimizing patient-specific therapy based on germline genetics.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4506. doi:1538-7445.AM2012-4506" @default.
• W2059008055 created "2016-06-24" @default.
• W2059008055 creator A5013955477 @default.
• W2059008055 creator A5021025628 @default.
• W2059008055 creator A5022722713 @default.
• W2059008055 creator A5026076619 @default.
• W2059008055 creator A5052680748 @default.
• W2059008055 creator A5064494204 @default.
• W2059008055 creator A5079655559 @default.
• W2059008055 date "2012-04-15" @default.
• W2059008055 modified "2023-09-25" @default.
• W2059008055 title "Abstract 4506: TNFRSF10B polymorphisms and haplotypes predicts survival in non-small cell lung cancer patients" @default.
• W2059008055 doi "https://doi.org/10.1158/1538-7445.am2012-4506" @default.
• W2059008055 hasPublicationYear "2012" @default.
• W2059008055 type Work @default.
• W2059008055 sameAs 2059008055 @default.
• W2059008055 citedByCount "1" @default.
• W2059008055 countsByYear W20590080552013 @default.
• W2059008055 crossrefType "proceedings-article" @default.
• W2059008055 hasAuthorship W2059008055A5013955477 @default.
• W2059008055 hasAuthorship W2059008055A5021025628 @default.
• W2059008055 hasAuthorship W2059008055A5022722713 @default.
• W2059008055 hasAuthorship W2059008055A5026076619 @default.
• W2059008055 hasAuthorship W2059008055A5052680748 @default.
• W2059008055 hasAuthorship W2059008055A5064494204 @default.
• W2059008055 hasAuthorship W2059008055A5079655559 @default.
• W2059008055 hasConcept C104317684 @default.
• W2059008055 hasConcept C121608353 @default.
• W2059008055 hasConcept C126322002 @default.
• W2059008055 hasConcept C135763542 @default.
• W2059008055 hasConcept C143998085 @default.
• W2059008055 hasConcept C153209595 @default.
• W2059008055 hasConcept C203014093 @default.
• W2059008055 hasConcept C207103383 @default.
• W2059008055 hasConcept C2776256026 @default.
• W2059008055 hasConcept C2779372377 @default.
• W2059008055 hasConcept C35605836 @default.
• W2059008055 hasConcept C44249647 @default.
• W2059008055 hasConcept C502942594 @default.
• W2059008055 hasConcept C50382708 @default.
• W2059008055 hasConcept C54355233 @default.
• W2059008055 hasConcept C555283112 @default.
• W2059008055 hasConcept C71924100 @default.
• W2059008055 hasConcept C86803240 @default.
• W2059008055 hasConceptScore W2059008055C104317684 @default.
• W2059008055 hasConceptScore W2059008055C121608353 @default.
• W2059008055 hasConceptScore W2059008055C126322002 @default.
• W2059008055 hasConceptScore W2059008055C135763542 @default.
• W2059008055 hasConceptScore W2059008055C143998085 @default.
• W2059008055 hasConceptScore W2059008055C153209595 @default.
• W2059008055 hasConceptScore W2059008055C203014093 @default.
• W2059008055 hasConceptScore W2059008055C207103383 @default.
• W2059008055 hasConceptScore W2059008055C2776256026 @default.
• W2059008055 hasConceptScore W2059008055C2779372377 @default.
• W2059008055 hasConceptScore W2059008055C35605836 @default.
• W2059008055 hasConceptScore W2059008055C44249647 @default.
• W2059008055 hasConceptScore W2059008055C502942594 @default.
• W2059008055 hasConceptScore W2059008055C50382708 @default.
• W2059008055 hasConceptScore W2059008055C54355233 @default.
• W2059008055 hasConceptScore W2059008055C555283112 @default.
• W2059008055 hasConceptScore W2059008055C71924100 @default.
• W2059008055 hasConceptScore W2059008055C86803240 @default.
• W2059008055 hasLocation W20590080551 @default.
• W2059008055 hasOpenAccess W2059008055 @default.
• W2059008055 hasPrimaryLocation W20590080551 @default.
• W2059008055 hasRelatedWork W1800397770 @default.
• W2059008055 hasRelatedWork W2002717103 @default.
• W2059008055 hasRelatedWork W2017585004 @default.
• W2059008055 hasRelatedWork W2028687193 @default.
• W2059008055 hasRelatedWork W2029979054 @default.
• W2059008055 hasRelatedWork W2056619734 @default.
• W2059008055 hasRelatedWork W2081145678 @default.
• W2059008055 hasRelatedWork W2095950007 @default.
• W2059008055 hasRelatedWork W2120243407 @default.
• W2059008055 hasRelatedWork W2146803890 @default.
• W2059008055 hasRelatedWork W2147720211 @default.
• W2059008055 hasRelatedWork W2160192355 @default.
• W2059008055 hasRelatedWork W2168785246 @default.
• W2059008055 hasRelatedWork W2312586242 @default.
• W2059008055 hasRelatedWork W2312657913 @default.
• W2059008055 hasRelatedWork W2312889472 @default.
• W2059008055 hasRelatedWork W2325323744 @default.
• W2059008055 hasRelatedWork W2551497105 @default.
• W2059008055 hasRelatedWork W2894549870 @default.
• W2059008055 hasRelatedWork W2187695009 @default.
• W2059008055 isParatext "false" @default.
• W2059008055 isRetracted "false" @default.
• W2059008055 magId "2059008055" @default.
• W2059008055 workType "article" @default.