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- W2059011617 abstract "PurposeTo examine the effect of halothane on the cytosolic Ca2+ concentration ([Ca2+]i)-tension relationship of rat aortic smooth muscle.MethodsRat aortic rings without endothelia were loaded with the fluorescent Ca2+ indicator, Fura PE3-AM, and then mounted in organ baths. The changes in isometric tension and [Ca2+]i were measured simultaneously. In one series ionomycin (10 nM–3 μM) was added to normal Krebs’ solution cumulatively in the absence and presence of halothane ( 1.5%, 3%). In the other series, CaCl2 (0.3–3 mM) was added to Ca2+-free Krebs’ solution including high KCl (50 mM), phenylephrine (100 nM) or prostaglandin F2α (PGF2α, 1–3 μM) in the absence and presence of halothane (1.5%, 3%). The linear part of [Ca2+]i-tension relationship was analyzed by a linear regression.ResultsHalothane, 1.5%, had no effect on the normal [Ca2+]i-tension relationship obtained with the calcium ionophore, ionomycin (10 nM–3 μM), but halothane 3% decreased the slope of the relationship (0.239 ± 0.037 for control and 0.110 ± 0.010 for halothane 3%,P < 0.05). Halothane, 1.5% and 3%, did not change the [Ca2+]i-tension relationship obtained with CaCl2 (0.3–3 mM) in the presence of high KCl (50 mM) or phenylephrine ( 100 nM). In contrast, halothane, 3%, inhibited the intercept of [Ca2+]i-tension relationship obtained with CaCl2 (0.3–3 mM) in the presence of prostaglandin F2α (PGF2α′, 1–3 μM) (45.708 ± 4.233 for control and 26.997 ± 2.522 for halothane 3%, P < 0.0l).ConclusionHalothane decreases the Ca2+ sensitivity and that in the presence of PGF2." @default.
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- W2059011617 date "1999-12-01" @default.
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- W2059011617 title "Halothane decreases calcium sensitivity of rat aortic smooth muscle" @default.
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- W2059011617 doi "https://doi.org/10.1007/bf03015527" @default.
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