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- W2059022901 abstract "The 5-HT1A-receptor antagonist (S)-UH-301 (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin) completely antagonized the hypotension and bradycardia induced by (R) = 8-OH DPAT ((R)-8-hydroxy-2-(dipropylamino)tetralin) in conscious rats. (S)-UH-301 alone induced a weak hypertension, which might be due to its 5-HT1A-receptor antagonistic properties. (R)-UH-301 induced effects similar to those of (R)-8-OH DPAT, i.e., a short initial phase of hypertension followed by a long-lasting hypotension and bradycardia. Thus, (R)-UH-301 behaves as a 5-HT1A-receptor agonist and (S)-UH-301 as a 5-HT1A-receptor antagonist, abolishing the effects induced by (R)-8-OH DPAT." @default.
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- W2059022901 date "1991-07-01" @default.
- W2059022901 modified "2023-09-25" @default.
- W2059022901 title "(S)-UH-301 antagonizes (R)-8-OH-DPAT-indiiced cardiovascular effects in the rat" @default.
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- W2059022901 doi "https://doi.org/10.1016/0014-2999(91)90502-h" @default.
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