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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059025654> ?p ?o ?g. }

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• W2059025654 abstract "A racemic mixture of ganciclovir phosphonate was resolved by stereoselective phosphorylation using GMP kinase. The R-enantiomer of ganciclovir phosphonate was active against human cytomegalovirus but the S-enantiomer was less active. We show that enantiomeric selectivity of antiviral for ganciclovir phosphonate was conferred by stereoselective phosphorylations by mammalian enzymes, not by stereoselective inhibition of DNA polymerase from human cytomegalovirus." @default.
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• W2059025654 date "2000-01-01" @default.
• W2059025654 modified "2023-09-27" @default.
• W2059025654 title "Phosphorylation of Ganciclovir Phosphonate by Cellular GMP Kinase Determines the Stereoselectivity of Anti-Human Cytomegalovirus Activity" @default.
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• W2059025654 doi "https://doi.org/10.1080/15257770008033013" @default.
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