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• W2059043977 abstract "Studies of C. elegans vulval development have illuminated mechanisms underlying cell fate specification and elucidated intercellular signaling pathways [1Sternberg, P.W. (2005). Vulval development. In WormBook, The C. elegans Research Community, ed. 10.1895/wormbook.1.6.1, http://www.wormbook.org.Google Scholar]. The vulval precursor cells (VPCs) are spatially patterned during the L3 stage by the EGFR-Ras-MAPK-mediated inductive signal and the LIN-12/Notch-mediated lateral signal. The pattern is both precise and robust [2Braendle C. Félix M.A. Plasticity and errors of a robust developmental system in different environments.Dev. Cell. 2008; 15: 714-724Abstract Full Text Full Text PDF PubMed Scopus (95) Google Scholar] because of crosstalk between these pathways [3Sundaram M.V. The love-hate relationship between Ras and Notch.Genes Dev. 2005; 19: 1825-1839Crossref PubMed Scopus (151) Google Scholar]. Signaling is also regulated temporally, because constitutive activation of the spatial patterning pathways does not alter the timing of VPC fate specification [4Greenwald I.S. Sternberg P.W. Horvitz H.R. The lin-12 locus specifies cell fates in Caenorhabditis elegans.Cell. 1983; 34: 435-444Abstract Full Text PDF PubMed Scopus (404) Google Scholar, 5Ferguson E.L. Sternberg P.W. Horvitz H.R. A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans.Nature. 1987; 326: 259-267Crossref PubMed Scopus (250) Google Scholar]. The heterochronic genes, including the microRNA lin-4 and its target lin-14, constitute a temporal control mechanism used in different contexts [6Moss E.G. Heterochronic genes and the nature of developmental time.Curr. Biol. 2007; 17: R425-R434Abstract Full Text Full Text PDF PubMed Scopus (148) Google Scholar, 7Resnick T.D. McCulloch K.A. Rougvie A.E. miRNAs give worms the time of their lives: Small RNAs and temporal control in Caenorhabditis elegans.Dev. Dyn. 2010; 239: 1477-1489PubMed Google Scholar, 8Johnson R.W. Liu L.Y. Hanna-Rose W. Chamberlin H.M. The Caenorhabditis elegans heterochronic gene lin-14 coordinates temporal progression and maturation in the egg-laying system.Dev. Dyn. 2009; 238: 394-404Crossref PubMed Scopus (6) Google Scholar]. We find that lin-4 specifically controls the activity of LIN-12/Notch through lin-14, but not other known targets, and that persistent lin-14 blocks LIN-12 activity without interfering with the key events of LIN-12/Notch signal transduction. In the L2 stage, there is sufficient lin-14 activity to inhibit constitutive lin-12. Our results suggest that lin-4 and lin-14 contribute to spatial patterning through temporal gating of LIN-12. We propose that in the L2 stage, lin-14 sets a high threshold for LIN-12 activation to help prevent premature activation of LIN-12 by ligands expressed in other cells in the vicinity, thereby contributing to the precision and robustness of VPC fate patterning." @default.
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• W2059043977 date "2010-10-01" @default.
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• W2059043977 title "LIN-14 Inhibition of LIN-12 Contributes to Precision and Timing of C. elegans Vulval Fate Patterning" @default.
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• W2059043977 doi "https://doi.org/10.1016/j.cub.2010.09.055" @default.
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