FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059044152> ?p ?o ?g. }

• W2059044152 endingPage "569" @default.
• W2059044152 startingPage "555" @default.
• W2059044152 abstract "We have investigated the protective effects of pretreatment with the mitochondrial uncoupler 2,4-dinitrophenol on the cellular damage induced by metabolic inhibition (with cyanide and iodoacetic acid) and reperfusion in freshly isolated adult rat ventricular myocytes. Damage was assessed from changes in cell length and morphology measured using video microscopy. Intracellular Ca(2+), mitochondrial membrane potential, and NADH were measured using fura-2, tetramethylrhodamine ethyl ester and autofluorescence, respectively. During metabolic inhibition myocytes developed rigor, and on reperfusion 73.6+/-8.1% hypercontracted and 10.8+/-6.7% recovered contractile function in response to electrical stimulation. Intracellular Ca(2+) increased substantially, indicated by a rise in the fura-2 ratio (340/380 nm) on reperfusion from 0.86+/-0.04 to 1.93+/-0.18. Myocytes pretreated with substrate-free Tyrode containing 50 microm dinitrophenol showed reduced reperfusion injury: 29.0+/-7.4% of cells hypercontracted and 65.3+/-7.3% recovered contractile function (P<0.001 vs control). The fura-2 ratio on reperfusion was also lower at 1.01+/-0.08. Fluorescence measurements showed that dinitrophenol caused mitochondrial depolarisation, and decreased NADH. The presence of the substrates glucose and pyruvate reduced these effects, and abolished the protection against damage by metabolic inhibition and reperfusion. However protection was unaffected by block of ATP-sensitive potassium channels. Thus the protective effects of pretreatment with dinitrophenol may result from a reduction in NADH in response to mitochondrial depolarisation." @default.
• W2059044152 created "2016-06-24" @default.
• W2059044152 creator A5004469680 @default.
• W2059044152 creator A5016840513 @default.
• W2059044152 creator A5085791068 @default.
• W2059044152 date "2002-05-01" @default.
• W2059044152 modified "2023-09-27" @default.
• W2059044152 title "Dinitrophenol Pretreatment of Rat Ventricular Myocytes Protects Against Damage by Metabolic Inhibition and Reperfusion" @default.
• W2059044152 cites W2007294454 @default.
• W2059044152 cites W2007939778 @default.
• W2059044152 cites W2008117638 @default.
• W2059044152 cites W2009574988 @default.
• W2059044152 cites W2021284033 @default.
• W2059044152 cites W2033974730 @default.
• W2059044152 cites W2034368455 @default.
• W2059044152 cites W2038890366 @default.
• W2059044152 cites W2041587518 @default.
• W2059044152 cites W2042307161 @default.
• W2059044152 cites W2046712654 @default.
• W2059044152 cites W2048547503 @default.
• W2059044152 cites W2054742735 @default.
• W2059044152 cites W2063098872 @default.
• W2059044152 cites W2073225923 @default.
• W2059044152 cites W2076517369 @default.
• W2059044152 cites W2080222124 @default.
• W2059044152 cites W2080247060 @default.
• W2059044152 cites W2082159651 @default.
• W2059044152 cites W2086486507 @default.
• W2059044152 cites W2087004550 @default.
• W2059044152 cites W2096251685 @default.
• W2059044152 cites W2121962823 @default.
• W2059044152 cites W2122501550 @default.
• W2059044152 cites W2132506421 @default.
• W2059044152 cites W2133726443 @default.
• W2059044152 cites W2142333871 @default.
• W2059044152 cites W2145047965 @default.
• W2059044152 cites W2146217294 @default.
• W2059044152 cites W2168717950 @default.
• W2059044152 cites W2169806115 @default.
• W2059044152 cites W2237730056 @default.
• W2059044152 cites W2241448607 @default.
• W2059044152 cites W2315145259 @default.
• W2059044152 cites W2337457656 @default.
• W2059044152 cites W2736250357 @default.
• W2059044152 cites W76973019 @default.
• W2059044152 cites W2012571088 @default.
• W2059044152 doi "https://doi.org/10.1006/jmcc.2002.1536" @default.
• W2059044152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12056859" @default.
• W2059044152 hasPublicationYear "2002" @default.
• W2059044152 type Work @default.
• W2059044152 sameAs 2059044152 @default.
• W2059044152 citedByCount "52" @default.
• W2059044152 countsByYear W20590441522012 @default.
• W2059044152 countsByYear W20590441522013 @default.
• W2059044152 countsByYear W20590441522014 @default.
• W2059044152 countsByYear W20590441522015 @default.
• W2059044152 countsByYear W20590441522016 @default.
• W2059044152 countsByYear W20590441522018 @default.
• W2059044152 countsByYear W20590441522022 @default.
• W2059044152 countsByYear W20590441522023 @default.
• W2059044152 crossrefType "journal-article" @default.
• W2059044152 hasAuthorship W2059044152A5004469680 @default.
• W2059044152 hasAuthorship W2059044152A5016840513 @default.
• W2059044152 hasAuthorship W2059044152A5085791068 @default.
• W2059044152 hasConcept C126322002 @default.
• W2059044152 hasConcept C134018914 @default.
• W2059044152 hasConcept C181199279 @default.
• W2059044152 hasConcept C181911157 @default.
• W2059044152 hasConcept C185592680 @default.
• W2059044152 hasConcept C207200792 @default.
• W2059044152 hasConcept C2778421351 @default.
• W2059044152 hasConcept C2780130669 @default.
• W2059044152 hasConcept C2780197888 @default.
• W2059044152 hasConcept C28859421 @default.
• W2059044152 hasConcept C4141045 @default.
• W2059044152 hasConcept C55493867 @default.
• W2059044152 hasConcept C71924100 @default.
• W2059044152 hasConcept C79879829 @default.
• W2059044152 hasConcept C86803240 @default.
• W2059044152 hasConceptScore W2059044152C126322002 @default.
• W2059044152 hasConceptScore W2059044152C134018914 @default.
• W2059044152 hasConceptScore W2059044152C181199279 @default.
• W2059044152 hasConceptScore W2059044152C181911157 @default.
• W2059044152 hasConceptScore W2059044152C185592680 @default.
• W2059044152 hasConceptScore W2059044152C207200792 @default.
• W2059044152 hasConceptScore W2059044152C2778421351 @default.
• W2059044152 hasConceptScore W2059044152C2780130669 @default.
• W2059044152 hasConceptScore W2059044152C2780197888 @default.
• W2059044152 hasConceptScore W2059044152C28859421 @default.
• W2059044152 hasConceptScore W2059044152C4141045 @default.
• W2059044152 hasConceptScore W2059044152C55493867 @default.
• W2059044152 hasConceptScore W2059044152C71924100 @default.
• W2059044152 hasConceptScore W2059044152C79879829 @default.
• W2059044152 hasConceptScore W2059044152C86803240 @default.
• W2059044152 hasIssue "5" @default.
• W2059044152 hasLocation W20590441521 @default.
• W2059044152 hasLocation W20590441522 @default.
• W2059044152 hasOpenAccess W2059044152 @default.

• next