FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059046522> ?p ?o ?g. }

• W2059046522 endingPage "4592" @default.
• W2059046522 startingPage "4586" @default.
• W2059046522 abstract "In embryonic stem (ES) cells, bivalent chromatin domains containing H3K4me3 and H3K27me3 marks silence developmental genes, while keeping them poised for activation following differentiation. We have identified gene sets associated with H3K27me3 and H3K4me3 marks at transcription start sites in a high-grade ovarian serous tumour and examined their association with epigenetic silencing and malignant progression. This revealed novel silenced bivalent marked genes, not described previously for ES cells, which are significantly enriched for the PI3K (P<10−7) and TGF-β signalling pathways (P<10−5). We matched histone marked gene sets to gene expression sets of eight normal fallopian tubes and 499 high-grade serous malignant ovarian samples. This revealed a significant decrease in gene expression for the H3K27me3 and bivalent gene sets in malignant tissue. We then correlated H3K27me3 and bivalent gene sets to gene expression data of ovarian tumour ‘stem cell-like’ sustaining cells versus non-sustaining cells. This showed a significantly lower expression for the H3K27me3 and bivalent gene sets in the tumour-sustaining cells. Similarly, comparison of matched chemo-sensitive and chemo-resistant ovarian cell lines showed a significantly lower expression of H3K27me3/bivalent marked genes in the chemo-resistant compared with the chemo-sensitive cell line. Our analysis supports the hypothesis that bivalent marks are associated with epigenetic silencing in ovarian cancer. However it also suggests that additional tumour specific bivalent marks, to those known in ES cells, are present in tumours and may potentially influence the subsequent development of drug resistance and tumour progression." @default.
• W2059046522 created "2016-06-24" @default.
• W2059046522 creator A5025321863 @default.
• W2059046522 creator A5029460181 @default.
• W2059046522 creator A5037650011 @default.
• W2059046522 creator A5053758493 @default.
• W2059046522 creator A5055949709 @default.
• W2059046522 creator A5057010269 @default.
• W2059046522 creator A5059707543 @default.
• W2059046522 creator A5075772884 @default.
• W2059046522 date "2012-11-05" @default.
• W2059046522 modified "2023-09-28" @default.
• W2059046522 title "Chromatin H3K27me3/H3K4me3 histone marks define gene sets in high-grade serous ovarian cancer that distinguish malignant, tumour-sustaining and chemo-resistant ovarian tumour cells" @default.
• W2059046522 cites W1968931043 @default.
• W2059046522 cites W1976006503 @default.
• W2059046522 cites W1976731741 @default.
• W2059046522 cites W1978597789 @default.
• W2059046522 cites W1988023818 @default.
• W2059046522 cites W2042087070 @default.
• W2059046522 cites W2067563155 @default.
• W2059046522 cites W2072035127 @default.
• W2059046522 cites W2073229191 @default.
• W2059046522 cites W2077223423 @default.
• W2059046522 cites W2078284062 @default.
• W2059046522 cites W2081098333 @default.
• W2059046522 cites W2095900642 @default.
• W2059046522 cites W2109023646 @default.
• W2059046522 cites W2115954319 @default.
• W2059046522 cites W2118681186 @default.
• W2059046522 cites W2123696077 @default.
• W2059046522 cites W2124985265 @default.
• W2059046522 cites W2128397771 @default.
• W2059046522 cites W2131593373 @default.
• W2059046522 cites W2138784667 @default.
• W2059046522 cites W2142325703 @default.
• W2059046522 cites W2146648681 @default.
• W2059046522 cites W2152389213 @default.
• W2059046522 cites W2153424791 @default.
• W2059046522 cites W2162351543 @default.
• W2059046522 cites W2163368401 @default.
• W2059046522 cites W2170210082 @default.
• W2059046522 cites W2170989872 @default.
• W2059046522 cites W4211170507 @default.
• W2059046522 doi "https://doi.org/10.1038/onc.2012.477" @default.
• W2059046522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23128397" @default.
• W2059046522 hasPublicationYear "2012" @default.
• W2059046522 type Work @default.
• W2059046522 sameAs 2059046522 @default.
• W2059046522 citedByCount "72" @default.
• W2059046522 countsByYear W20590465222012 @default.
• W2059046522 countsByYear W20590465222013 @default.
• W2059046522 countsByYear W20590465222014 @default.
• W2059046522 countsByYear W20590465222015 @default.
• W2059046522 countsByYear W20590465222016 @default.
• W2059046522 countsByYear W20590465222017 @default.
• W2059046522 countsByYear W20590465222018 @default.
• W2059046522 countsByYear W20590465222019 @default.
• W2059046522 countsByYear W20590465222020 @default.
• W2059046522 countsByYear W20590465222021 @default.
• W2059046522 countsByYear W20590465222022 @default.
• W2059046522 countsByYear W20590465222023 @default.
• W2059046522 crossrefType "journal-article" @default.
• W2059046522 hasAuthorship W2059046522A5025321863 @default.
• W2059046522 hasAuthorship W2059046522A5029460181 @default.
• W2059046522 hasAuthorship W2059046522A5037650011 @default.
• W2059046522 hasAuthorship W2059046522A5053758493 @default.
• W2059046522 hasAuthorship W2059046522A5055949709 @default.
• W2059046522 hasAuthorship W2059046522A5057010269 @default.
• W2059046522 hasAuthorship W2059046522A5059707543 @default.
• W2059046522 hasAuthorship W2059046522A5075772884 @default.
• W2059046522 hasBestOaLocation W20590465221 @default.
• W2059046522 hasConcept C101762097 @default.
• W2059046522 hasConcept C104317684 @default.
• W2059046522 hasConcept C119056186 @default.
• W2059046522 hasConcept C121608353 @default.
• W2059046522 hasConcept C137338518 @default.
• W2059046522 hasConcept C150173356 @default.
• W2059046522 hasConcept C150194340 @default.
• W2059046522 hasConcept C167227067 @default.
• W2059046522 hasConcept C178790620 @default.
• W2059046522 hasConcept C185592680 @default.
• W2059046522 hasConcept C2776620830 @default.
• W2059046522 hasConcept C2780427987 @default.
• W2059046522 hasConcept C2780914512 @default.
• W2059046522 hasConcept C41091548 @default.
• W2059046522 hasConcept C502942594 @default.
• W2059046522 hasConcept C54355233 @default.
• W2059046522 hasConcept C544153396 @default.
• W2059046522 hasConcept C55493867 @default.
• W2059046522 hasConcept C64927066 @default.
• W2059046522 hasConcept C83640560 @default.
• W2059046522 hasConcept C86803240 @default.
• W2059046522 hasConceptScore W2059046522C101762097 @default.
• W2059046522 hasConceptScore W2059046522C104317684 @default.
• W2059046522 hasConceptScore W2059046522C119056186 @default.
• W2059046522 hasConceptScore W2059046522C121608353 @default.
• W2059046522 hasConceptScore W2059046522C137338518 @default.
• W2059046522 hasConceptScore W2059046522C150173356 @default.

• next