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• W2059052392 startingPage "159" @default.
• W2059052392 abstract "Lanosterol 14alpha-demethylase is a cytochrome P450 enzyme of the cholesterol biosynthetic pathway belonging to the CYP51 gene family which is the most evolutionarily conserved member of the CYP superfamily. Mammalian (human, mouse, rat, pig) CYP51 genes are unique in sharing several common characteristics: highly conserved exon/intron borders and proximal promoter structures, ubiquitous expression at the highest level in the testis, and appearance of testis-specific transcripts that arise from differential polyadenylation site usage. CYP51 protein demethylates lanosterol to form follicular fluid meiosis-activating sterol, FF-MAS, which is, besides being an intermediate of cholesterol biosynthesis, also a signaling sterol that accumulates in ovaries. CYP51 protein resides in the endoplasmatic reticulum of most cells and also in acrosomal membranes of spermatids where transport through the Golgi apparatus is suggested. While sterol regulatory element binding protein (SREBP)-dependent transcriptional regulation of CYP51 contributes to synthesis of cholesterol, the germ-cell-specific cAMP/CREMtau-dependent upregulation might contribute to increased production of MAS." @default.
• W2059052392 created "2016-06-24" @default.
• W2059052392 creator A5018486258 @default.
• W2059052392 creator A5035439594 @default.
• W2059052392 creator A5066229737 @default.
• W2059052392 date "2003-01-01" @default.
• W2059052392 modified "2023-10-12" @default.
• W2059052392 title "Many facets of mammalian lanosterol 14α-demethylase from the evolutionarily conserved cytochrome P450 family CYP51" @default.
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• W2059052392 doi "https://doi.org/10.1016/s0003-9861(02)00418-6" @default.
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• W2059052392 hasPublicationYear "2003" @default.
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