Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059053018> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2059053018 endingPage "685" @default.
- W2059053018 startingPage "676" @default.
- W2059053018 abstract "A negating functionality is fundamental to information processing of logic circuits within cells and computers. Aiming to adapt unutilized electronic concepts to the interrogation of signaling circuits in cells, we first took a bottom-up strategy whereby we created protein-based devices that perform negating Boolean logic operations such as NOT, NOR, NAND, and N-IMPLY. These devices function in living cells within a minute by precisely commanding the localization of an activator molecule among three subcellular spaces. We networked these synthetic gates to an endogenous signaling circuit and devised a physiological output. In search of logic functions in signal transduction, we next took a top–down approach and computationally screened 108 signaling pathways to identify commonalities and differences between these biological pathways and electronic circuits. This combination of synthetic and systems approaches will guide us in developing foundations for deconstruction of intricate cell signaling, as well as construction of biomolecular computers." @default.
- W2059053018 created "2016-06-24" @default.
- W2059053018 creator A5007168286 @default.
- W2059053018 creator A5016953377 @default.
- W2059053018 creator A5038005619 @default.
- W2059053018 date "2014-07-07" @default.
- W2059053018 modified "2023-10-06" @default.
- W2059053018 title "Cellular Signaling Circuits Interfaced with Synthetic, Post-Translational, Negating Boolean Logic Devices" @default.
- W2059053018 cites W1990852626 @default.
- W2059053018 cites W1999259384 @default.
- W2059053018 cites W2013075289 @default.
- W2059053018 cites W2021170096 @default.
- W2059053018 cites W2029852810 @default.
- W2059053018 cites W2032021721 @default.
- W2059053018 cites W2039874742 @default.
- W2059053018 cites W2045972058 @default.
- W2059053018 cites W2046138985 @default.
- W2059053018 cites W2048084175 @default.
- W2059053018 cites W2051698507 @default.
- W2059053018 cites W2062573403 @default.
- W2059053018 cites W2064894346 @default.
- W2059053018 cites W2066227044 @default.
- W2059053018 cites W2071199281 @default.
- W2059053018 cites W2076425379 @default.
- W2059053018 cites W2087879073 @default.
- W2059053018 cites W2090876232 @default.
- W2059053018 cites W2099536948 @default.
- W2059053018 cites W2100013955 @default.
- W2059053018 cites W2100249996 @default.
- W2059053018 cites W2149778176 @default.
- W2059053018 cites W2158313010 @default.
- W2059053018 cites W2169082014 @default.
- W2059053018 cites W2318093937 @default.
- W2059053018 doi "https://doi.org/10.1021/sb500222z" @default.
- W2059053018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4169742" @default.
- W2059053018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25000210" @default.
- W2059053018 hasPublicationYear "2014" @default.
- W2059053018 type Work @default.
- W2059053018 sameAs 2059053018 @default.
- W2059053018 citedByCount "9" @default.
- W2059053018 countsByYear W20590530182016 @default.
- W2059053018 countsByYear W20590530182019 @default.
- W2059053018 countsByYear W20590530182020 @default.
- W2059053018 countsByYear W20590530182021 @default.
- W2059053018 countsByYear W20590530182022 @default.
- W2059053018 countsByYear W20590530182023 @default.
- W2059053018 crossrefType "journal-article" @default.
- W2059053018 hasAuthorship W2059053018A5007168286 @default.
- W2059053018 hasAuthorship W2059053018A5016953377 @default.
- W2059053018 hasAuthorship W2059053018A5038005619 @default.
- W2059053018 hasBestOaLocation W20590530181 @default.
- W2059053018 hasConcept C11413529 @default.
- W2059053018 hasConcept C119599485 @default.
- W2059053018 hasConcept C124296912 @default.
- W2059053018 hasConcept C127413603 @default.
- W2059053018 hasConcept C131017901 @default.
- W2059053018 hasConcept C134146338 @default.
- W2059053018 hasConcept C187455244 @default.
- W2059053018 hasConcept C191908910 @default.
- W2059053018 hasConcept C41008148 @default.
- W2059053018 hasConcept C70721500 @default.
- W2059053018 hasConcept C86803240 @default.
- W2059053018 hasConceptScore W2059053018C11413529 @default.
- W2059053018 hasConceptScore W2059053018C119599485 @default.
- W2059053018 hasConceptScore W2059053018C124296912 @default.
- W2059053018 hasConceptScore W2059053018C127413603 @default.
- W2059053018 hasConceptScore W2059053018C131017901 @default.
- W2059053018 hasConceptScore W2059053018C134146338 @default.
- W2059053018 hasConceptScore W2059053018C187455244 @default.
- W2059053018 hasConceptScore W2059053018C191908910 @default.
- W2059053018 hasConceptScore W2059053018C41008148 @default.
- W2059053018 hasConceptScore W2059053018C70721500 @default.
- W2059053018 hasConceptScore W2059053018C86803240 @default.
- W2059053018 hasFunder F4320320893 @default.
- W2059053018 hasIssue "9" @default.
- W2059053018 hasLocation W20590530181 @default.
- W2059053018 hasLocation W20590530182 @default.
- W2059053018 hasLocation W20590530183 @default.
- W2059053018 hasLocation W20590530184 @default.
- W2059053018 hasOpenAccess W2059053018 @default.
- W2059053018 hasPrimaryLocation W20590530181 @default.
- W2059053018 hasRelatedWork W1761011154 @default.
- W2059053018 hasRelatedWork W1974817749 @default.
- W2059053018 hasRelatedWork W2118522716 @default.
- W2059053018 hasRelatedWork W2124294758 @default.
- W2059053018 hasRelatedWork W2149778176 @default.
- W2059053018 hasRelatedWork W2163861263 @default.
- W2059053018 hasRelatedWork W3121501158 @default.
- W2059053018 hasRelatedWork W3140306724 @default.
- W2059053018 hasRelatedWork W4200292742 @default.
- W2059053018 hasRelatedWork W4239147027 @default.
- W2059053018 hasVolume "3" @default.
- W2059053018 isParatext "false" @default.
- W2059053018 isRetracted "false" @default.
- W2059053018 magId "2059053018" @default.
- W2059053018 workType "article" @default.