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• W2059054935 abstract "Analogues of the amphibian neuropeptide, bombesin, and of the mammalian homologue, gastrin-releasing peptide, have been synthesized and their biological activity studied in small cell lung carcinoma and rat pancreatic acinar cells. The compounds are truncated sequences of the active tetradecapeptide BN(1-14) or GRP(20-27). Peptides were cyclized between position 5 or 7 and the carboxyl end of the des-Met14 fragment with D and L Ala11 and Lys5 substitutions, as well as various N-terminal groups attached. The smallest cyclic peptide, BN(7-13), bound to SCLC membranes with microM potency and inhibited BN stimulation of intracellular Ca++ levels. The most potent inhibitor is N-chloroambucil-[His7,D-Ala11]BN(7-13)ethyl ester, which antagonized BN function in SCLC and acinar cells with nM potency and also inhibited clonal growth of carcinoma cell lines." @default.
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• W2059054935 date "1995-01-01" @default.
• W2059054935 modified "2023-10-16" @default.
• W2059054935 title "Inhibitory cyclic analogues and chlorambucil derivatives of bombesin-like peptides" @default.
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• W2059054935 doi "https://doi.org/10.1016/0196-9781(95)00074-t" @default.
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