FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059060982> ?p ?o ?g. }

• W2059060982 endingPage "e28750" @default.
• W2059060982 startingPage "e28750" @default.
• W2059060982 abstract "Esters of phthalic acid (phthalates) are largely used in industrial plastics, medical devices, and pharmaceutical formulations. They are easily released from plastics into the environment and can be found in measurable levels in human fluids. Phthalates are agonists for peroxisome proliferator-activated receptors (PPARs), through which they regulate translocator protein (TSPO; 18 kDa) transcription in a tissue-specific manner. TSPO is a drug- and cholesterol-binding protein involved in mitochondrial respiration, steroid formation, and cell proliferation. TSPO has been shown to increase during differentiation and decrease during maturation in mouse adipocytes. The purpose of this study was to establish the effect of mono-(2-ethylhexyl) phthalate (MEHP) on the differentiation of human SW 872 preadipocyte cells, and examine the role of TSPO in the process. After 4 days of treatment with 10 µM MEHP, we observed changes in the transcription of acetyl-CoA carboxylase alpha, adenosine triphosphate citrate lyase, glucose transporters 1 and 4, and the S100 calcium binding protein B, all of which are markers of preadipocyte differentiation. These observed gene expression changes coincided with a decrease in cellular proliferation without affecting cellular triglyceride content. Taken together, these data suggest that MEHP exerts a differentiating effect on human preadipocytes. Interestingly, MEHP was able to temporarily increase TSPO mRNA levels through the PPAR-α and β/δ pathways. These results suggest that TSPO can be considered an important player in the differentiation process itself, or alternatively a factor whose presence is essential for adipocyte development." @default.
• W2059060982 created "2016-06-24" @default.
• W2059060982 creator A5004323594 @default.
• W2059060982 creator A5058801218 @default.
• W2059060982 creator A5075730868 @default.
• W2059060982 creator A5079307983 @default.
• W2059060982 date "2011-12-21" @default.
• W2059060982 modified "2023-09-28" @default.
• W2059060982 title "The Endocrine Disruptor Mono-(2-Ethylhexyl) Phthalate Affects the Differentiation of Human Liposarcoma Cells (SW 872)" @default.
• W2059060982 cites W1647126819 @default.
• W2059060982 cites W1843404873 @default.
• W2059060982 cites W1970681652 @default.
• W2059060982 cites W1972749206 @default.
• W2059060982 cites W1982728225 @default.
• W2059060982 cites W1983254116 @default.
• W2059060982 cites W1985077504 @default.
• W2059060982 cites W1989067043 @default.
• W2059060982 cites W1992118543 @default.
• W2059060982 cites W1993873562 @default.
• W2059060982 cites W1995862976 @default.
• W2059060982 cites W1999281859 @default.
• W2059060982 cites W2003800568 @default.
• W2059060982 cites W2011341002 @default.
• W2059060982 cites W2016298359 @default.
• W2059060982 cites W2018878700 @default.
• W2059060982 cites W2022394991 @default.
• W2059060982 cites W2025347049 @default.
• W2059060982 cites W2027874598 @default.
• W2059060982 cites W2031688634 @default.
• W2059060982 cites W2032090234 @default.
• W2059060982 cites W2034450620 @default.
• W2059060982 cites W2038496515 @default.
• W2059060982 cites W2046478889 @default.
• W2059060982 cites W2047687395 @default.
• W2059060982 cites W2047982128 @default.
• W2059060982 cites W2055691011 @default.
• W2059060982 cites W2056250382 @default.
• W2059060982 cites W2071912432 @default.
• W2059060982 cites W2072700306 @default.
• W2059060982 cites W2076945625 @default.
• W2059060982 cites W2077728004 @default.
• W2059060982 cites W2081550219 @default.
• W2059060982 cites W2083888364 @default.
• W2059060982 cites W2089158765 @default.
• W2059060982 cites W2102341698 @default.
• W2059060982 cites W2109977046 @default.
• W2059060982 cites W2110722372 @default.
• W2059060982 cites W2120736359 @default.
• W2059060982 cites W2122488988 @default.
• W2059060982 cites W2124595203 @default.
• W2059060982 cites W2124890764 @default.
• W2059060982 cites W2129011493 @default.
• W2059060982 cites W2129138669 @default.
• W2059060982 cites W2133734192 @default.
• W2059060982 cites W2139046356 @default.
• W2059060982 cites W2141220013 @default.
• W2059060982 cites W2142761929 @default.
• W2059060982 cites W2146542085 @default.
• W2059060982 cites W2148016814 @default.
• W2059060982 cites W2154208403 @default.
• W2059060982 cites W2159270178 @default.
• W2059060982 cites W2170831952 @default.
• W2059060982 cites W3185097245 @default.
• W2059060982 doi "https://doi.org/10.1371/journal.pone.0028750" @default.
• W2059060982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3244402" @default.
• W2059060982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22205965" @default.
• W2059060982 hasPublicationYear "2011" @default.
• W2059060982 type Work @default.
• W2059060982 sameAs 2059060982 @default.
• W2059060982 citedByCount "46" @default.
• W2059060982 countsByYear W20590609822012 @default.
• W2059060982 countsByYear W20590609822013 @default.
• W2059060982 countsByYear W20590609822014 @default.
• W2059060982 countsByYear W20590609822015 @default.
• W2059060982 countsByYear W20590609822016 @default.
• W2059060982 countsByYear W20590609822017 @default.
• W2059060982 countsByYear W20590609822018 @default.
• W2059060982 countsByYear W20590609822019 @default.
• W2059060982 countsByYear W20590609822020 @default.
• W2059060982 countsByYear W20590609822021 @default.
• W2059060982 countsByYear W20590609822022 @default.
• W2059060982 countsByYear W20590609822023 @default.
• W2059060982 crossrefType "journal-article" @default.
• W2059060982 hasAuthorship W2059060982A5004323594 @default.
• W2059060982 hasAuthorship W2059060982A5058801218 @default.
• W2059060982 hasAuthorship W2059060982A5075730868 @default.
• W2059060982 hasAuthorship W2059060982A5079307983 @default.
• W2059060982 hasBestOaLocation W20590609821 @default.
• W2059060982 hasConcept C104317684 @default.
• W2059060982 hasConcept C122927707 @default.
• W2059060982 hasConcept C126322002 @default.
• W2059060982 hasConcept C127078168 @default.
• W2059060982 hasConcept C134018914 @default.
• W2059060982 hasConcept C148738053 @default.
• W2059060982 hasConcept C170493617 @default.
• W2059060982 hasConcept C171089720 @default.
• W2059060982 hasConcept C178790620 @default.
• W2059060982 hasConcept C185592680 @default.

• next