FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059062014> ?p ?o ?g. }

• W2059062014 endingPage "12924" @default.
• W2059062014 startingPage "12919" @default.
• W2059062014 abstract "The transcription factor Osterix (Osx) is required for osteoblast differentiation and bone formation during embryonic development, but it is not known whether Osx has an essential function in postnatal bone growth and in bone homeostasis. Conditional deletion of Osx at several time points postnatally revealed that Osx was essential for osteoblast differentiation and new bone formation in growing and adult bones. Additionally, inactivation of Osx in bones severely disrupted the maturation, morphology, and function of osteocytes. These findings identify Osx as having an essential role in the cell-specific genetic program of osteocytes. Interestingly, Osx inactivation also led to the massive accumulation of unresorbed calcified cartilage in a large area below the growth plate of endochondral bones. This specific area was also marked by an unanticipated almost complete lack of bone marrow cells and a marked decrease in the density and size of osteoclasts. This diminished density of osteoclasts could contribute to the lack of resorption of mineralized cartilage. In addition, we speculate that the abnormally accumulated, mainly naked cartilage represents an unfavorable substrate for osteoclasts. Our study identifies Osx as an essential multifunctional player in postnatal bone growth and homeostasis." @default.
• W2059062014 created "2016-06-24" @default.
• W2059062014 creator A5004983828 @default.
• W2059062014 creator A5035291764 @default.
• W2059062014 creator A5056450584 @default.
• W2059062014 creator A5057469947 @default.
• W2059062014 creator A5063358317 @default.
• W2059062014 creator A5077928042 @default.
• W2059062014 creator A5087832026 @default.
• W2059062014 creator A5090003520 @default.
• W2059062014 date "2010-07-06" @default.
• W2059062014 modified "2023-10-10" @default.
• W2059062014 title "Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice" @default.
• W2059062014 cites W1981284961 @default.
• W2059062014 cites W1983026473 @default.
• W2059062014 cites W1994596418 @default.
• W2059062014 cites W1997812904 @default.
• W2059062014 cites W2003457351 @default.
• W2059062014 cites W2011828467 @default.
• W2059062014 cites W2014362480 @default.
• W2059062014 cites W2038457945 @default.
• W2059062014 cites W2041590882 @default.
• W2059062014 cites W2042742511 @default.
• W2059062014 cites W2043758876 @default.
• W2059062014 cites W2051772576 @default.
• W2059062014 cites W2051959338 @default.
• W2059062014 cites W2093353711 @default.
• W2059062014 cites W2099165911 @default.
• W2059062014 cites W2100039503 @default.
• W2059062014 cites W2103945127 @default.
• W2059062014 cites W2104779362 @default.
• W2059062014 cites W2110334171 @default.
• W2059062014 cites W2114529565 @default.
• W2059062014 cites W2122367477 @default.
• W2059062014 cites W2126238352 @default.
• W2059062014 cites W2148854582 @default.
• W2059062014 doi "https://doi.org/10.1073/pnas.0912855107" @default.
• W2059062014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2919908" @default.
• W2059062014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20615976" @default.
• W2059062014 hasPublicationYear "2010" @default.
• W2059062014 type Work @default.
• W2059062014 sameAs 2059062014 @default.
• W2059062014 citedByCount "262" @default.
• W2059062014 countsByYear W20590620142012 @default.
• W2059062014 countsByYear W20590620142013 @default.
• W2059062014 countsByYear W20590620142014 @default.
• W2059062014 countsByYear W20590620142015 @default.
• W2059062014 countsByYear W20590620142016 @default.
• W2059062014 countsByYear W20590620142017 @default.
• W2059062014 countsByYear W20590620142018 @default.
• W2059062014 countsByYear W20590620142019 @default.
• W2059062014 countsByYear W20590620142020 @default.
• W2059062014 countsByYear W20590620142021 @default.
• W2059062014 countsByYear W20590620142022 @default.
• W2059062014 countsByYear W20590620142023 @default.
• W2059062014 crossrefType "journal-article" @default.
• W2059062014 hasAuthorship W2059062014A5004983828 @default.
• W2059062014 hasAuthorship W2059062014A5035291764 @default.
• W2059062014 hasAuthorship W2059062014A5056450584 @default.
• W2059062014 hasAuthorship W2059062014A5057469947 @default.
• W2059062014 hasAuthorship W2059062014A5063358317 @default.
• W2059062014 hasAuthorship W2059062014A5077928042 @default.
• W2059062014 hasAuthorship W2059062014A5087832026 @default.
• W2059062014 hasAuthorship W2059062014A5090003520 @default.
• W2059062014 hasBestOaLocation W20590620142 @default.
• W2059062014 hasConcept C104317684 @default.
• W2059062014 hasConcept C105702510 @default.
• W2059062014 hasConcept C126322002 @default.
• W2059062014 hasConcept C134018914 @default.
• W2059062014 hasConcept C148738053 @default.
• W2059062014 hasConcept C17938293 @default.
• W2059062014 hasConcept C185592680 @default.
• W2059062014 hasConcept C202751555 @default.
• W2059062014 hasConcept C2778260815 @default.
• W2059062014 hasConcept C2780550940 @default.
• W2059062014 hasConcept C55493867 @default.
• W2059062014 hasConcept C63645605 @default.
• W2059062014 hasConcept C673006 @default.
• W2059062014 hasConcept C71924100 @default.
• W2059062014 hasConcept C86803240 @default.
• W2059062014 hasConcept C95444343 @default.
• W2059062014 hasConceptScore W2059062014C104317684 @default.
• W2059062014 hasConceptScore W2059062014C105702510 @default.
• W2059062014 hasConceptScore W2059062014C126322002 @default.
• W2059062014 hasConceptScore W2059062014C134018914 @default.
• W2059062014 hasConceptScore W2059062014C148738053 @default.
• W2059062014 hasConceptScore W2059062014C17938293 @default.
• W2059062014 hasConceptScore W2059062014C185592680 @default.
• W2059062014 hasConceptScore W2059062014C202751555 @default.
• W2059062014 hasConceptScore W2059062014C2778260815 @default.
• W2059062014 hasConceptScore W2059062014C2780550940 @default.
• W2059062014 hasConceptScore W2059062014C55493867 @default.
• W2059062014 hasConceptScore W2059062014C63645605 @default.
• W2059062014 hasConceptScore W2059062014C673006 @default.
• W2059062014 hasConceptScore W2059062014C71924100 @default.
• W2059062014 hasConceptScore W2059062014C86803240 @default.
• W2059062014 hasConceptScore W2059062014C95444343 @default.
• W2059062014 hasIssue "29" @default.

• next