FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059068052> ?p ?o ?g. }

• W2059068052 endingPage "3422" @default.
• W2059068052 startingPage "3413" @default.
• W2059068052 abstract "A subset of effector/memory CD8+ T cells expresses natural killer cell receptors (NKR). Expression of inhibitory NKR at that stage of T cell differentiation is poorly understood. Interestingly, recent studies in mice indicated that transgenic expression of an inhibitory NKR induced the accumulation of memory T cells by inhibiting activation-induced cell death (AICD). To further understand the role of inhibitory NKR on T cells, we characterized the subset of human peripheral T cells expressing the inhibitory NKR, CD158b, and studied the modulation of antigen-driven T cell expansion by an endogenous inhibitory NKR. We found that CD158b expression was confined to a population of CD8+TCRαβ+ effector T cells as defined by a CD45RA+CCR7– phenotype and high constitutive expression of granzyme B1. Few cells expressed the activating form CD158j in the absence of CD158b. Functionally, engagement of CD158b by MHC ligands diminished early TCR signaling, as well as AICD. However, the reduced AICD did not rescue cells for proliferation, since T cell expansion in the presence of CD158b triggering was impaired. Expression of inhibitory NKR on effector CD8+ T cells may explain in part the poor replicative capacity of T cells at that stage of differentiation." @default.
• W2059068052 created "2016-06-24" @default.
• W2059068052 creator A5017937013 @default.
• W2059068052 creator A5024514544 @default.
• W2059068052 creator A5026655877 @default.
• W2059068052 creator A5046698256 @default.
• W2059068052 creator A5089647936 @default.
• W2059068052 date "2004-12-01" @default.
• W2059068052 modified "2023-09-30" @default.
• W2059068052 title "Expression of inhibitory KIR is confined to CD8+ effector T?cells and limits their proliferative capacity" @default.
• W2059068052 cites W1484345440 @default.
• W2059068052 cites W1525558893 @default.
• W2059068052 cites W1575885906 @default.
• W2059068052 cites W1594345612 @default.
• W2059068052 cites W1612595544 @default.
• W2059068052 cites W1635281590 @default.
• W2059068052 cites W1934719640 @default.
• W2059068052 cites W1986376227 @default.
• W2059068052 cites W1987625640 @default.
• W2059068052 cites W1990279113 @default.
• W2059068052 cites W2016359645 @default.
• W2059068052 cites W2016899802 @default.
• W2059068052 cites W2034308733 @default.
• W2059068052 cites W2037133606 @default.
• W2059068052 cites W2040423510 @default.
• W2059068052 cites W2059378562 @default.
• W2059068052 cites W2061097078 @default.
• W2059068052 cites W2063429059 @default.
• W2059068052 cites W2066053659 @default.
• W2059068052 cites W2067185217 @default.
• W2059068052 cites W2076308114 @default.
• W2059068052 cites W2080439606 @default.
• W2059068052 cites W2081561748 @default.
• W2059068052 cites W2082645096 @default.
• W2059068052 cites W2083233431 @default.
• W2059068052 cites W2083920899 @default.
• W2059068052 cites W2090786116 @default.
• W2059068052 cites W2096005822 @default.
• W2059068052 cites W2102123495 @default.
• W2059068052 cites W2104595884 @default.
• W2059068052 cites W2113393586 @default.
• W2059068052 cites W2117003890 @default.
• W2059068052 cites W2120472894 @default.
• W2059068052 cites W2126302947 @default.
• W2059068052 cites W2130035360 @default.
• W2059068052 cites W2131596029 @default.
• W2059068052 cites W2132385533 @default.
• W2059068052 cites W2146374053 @default.
• W2059068052 cites W2147453145 @default.
• W2059068052 cites W2152989802 @default.
• W2059068052 cites W2170740674 @default.
• W2059068052 cites W2188007762 @default.
• W2059068052 cites W2408475824 @default.
• W2059068052 doi "https://doi.org/10.1002/eji.200324756" @default.
• W2059068052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15549734" @default.
• W2059068052 hasPublicationYear "2004" @default.
• W2059068052 type Work @default.
• W2059068052 sameAs 2059068052 @default.
• W2059068052 citedByCount "32" @default.
• W2059068052 countsByYear W20590680522014 @default.
• W2059068052 countsByYear W20590680522017 @default.
• W2059068052 countsByYear W20590680522018 @default.
• W2059068052 countsByYear W20590680522020 @default.
• W2059068052 countsByYear W20590680522021 @default.
• W2059068052 countsByYear W20590680522023 @default.
• W2059068052 crossrefType "journal-article" @default.
• W2059068052 hasAuthorship W2059068052A5017937013 @default.
• W2059068052 hasAuthorship W2059068052A5024514544 @default.
• W2059068052 hasAuthorship W2059068052A5026655877 @default.
• W2059068052 hasAuthorship W2059068052A5046698256 @default.
• W2059068052 hasAuthorship W2059068052A5089647936 @default.
• W2059068052 hasConcept C129374314 @default.
• W2059068052 hasConcept C139563560 @default.
• W2059068052 hasConcept C147483822 @default.
• W2059068052 hasConcept C154317977 @default.
• W2059068052 hasConcept C167672396 @default.
• W2059068052 hasConcept C202751555 @default.
• W2059068052 hasConcept C203014093 @default.
• W2059068052 hasConcept C2776090121 @default.
• W2059068052 hasConcept C51785407 @default.
• W2059068052 hasConcept C54355233 @default.
• W2059068052 hasConcept C67662055 @default.
• W2059068052 hasConcept C86803240 @default.
• W2059068052 hasConcept C8891405 @default.
• W2059068052 hasConcept C95444343 @default.
• W2059068052 hasConceptScore W2059068052C129374314 @default.
• W2059068052 hasConceptScore W2059068052C139563560 @default.
• W2059068052 hasConceptScore W2059068052C147483822 @default.
• W2059068052 hasConceptScore W2059068052C154317977 @default.
• W2059068052 hasConceptScore W2059068052C167672396 @default.
• W2059068052 hasConceptScore W2059068052C202751555 @default.
• W2059068052 hasConceptScore W2059068052C203014093 @default.
• W2059068052 hasConceptScore W2059068052C2776090121 @default.
• W2059068052 hasConceptScore W2059068052C51785407 @default.
• W2059068052 hasConceptScore W2059068052C54355233 @default.
• W2059068052 hasConceptScore W2059068052C67662055 @default.
• W2059068052 hasConceptScore W2059068052C86803240 @default.
• W2059068052 hasConceptScore W2059068052C8891405 @default.

• next