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- W2059076968 abstract "Dispersion of the cardiac action potential duration (APD) is known to influence the susceptibility of cardiac tissue to arrhythmias. Several experimental studies have revealed that APD can be modulated by the activation sequence. Our lab has recently shown strong correlations between APD and activation time (AT) in hearts from small rodents. However, a recent computational study indicated that the magnitude of such APD modulation may not be consistent across species. Therefore, the present study sought to compare experimentally APD modulation by activation sequence in rat and pig. Optical imaging using the voltage-sensitive dye Di-4-ANEPPS was performed in Langendorff perfused rat hearts (n=4) and coronary perfused pig left ventricular slabs (n=5). The left ventricular mid-free wall was paced at 6Hz (rat) and 2Hz (pig), close to their intrinsic heart rate, and optical action potentials were acquired for 5s. The mean APD near the pacing site (at 4ms AT) was 44.9 ± 9.4 ms in rat and 142.2 ± 11.3 ms in pig. A significant decrease of APD was revealed at larger AT in rat (37.2 ± 9.5 ms at 10ms AT, P0.05). Plotting APD as a function of AT revealed a linear correlation of APD with AT. Slope analysis revealed a decreasing trend in rats (mean slope = −0.79 ± 0.26) whilst pigs showed no such modulation of APD (mean slope = 0.29 ± 0.22) Heterogeneity, defined as the APD covariance over the whole field of view, was 0.10 in rat and 0.05 in pig (P<0.05). In conclusion, APD can be strongly modulated by the activation sequence in hearts from small rodents whilst this modulation is absent in pig myocardium. This study emphasises the importance of APD heterogeneity induced by activation sequence and differences between species." @default.
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- W2059076968 date "2010-01-01" @default.
- W2059076968 modified "2023-09-25" @default.
- W2059076968 title "Action Potential Duration Modulation by Activation Sequence in Rat Vs. Pig Myocardium" @default.
- W2059076968 doi "https://doi.org/10.1016/j.bpj.2009.12.2882" @default.
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