FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059090970> ?p ?o ?g. }

• W2059090970 endingPage "250" @default.
• W2059090970 startingPage "245" @default.
• W2059090970 abstract "Studying peripheral blood transcriptome in the quest for translational markers of toxicity is considered to be an attractive offshoot in the field of toxicogenomics. Moreover, it is acknowledged that, xenobiotics which cause a toxic response through similar mechanisms lead to distinctive gene expression patterns. The current study was undertaken to gauge the response of an accessible surrogate tissue, such as blood, to drug-induced perturbations aimed at deriving gene expression patterns. Human peripheral blood mononuclear cells (hPBMC) were exposed to conventional drugs, with reported kidney and/or liver injury, in order to determine their transcriptomic response. Test drugs were divided into two classes viz., drugs affecting kidney (cyclophosphamide, amphotericin B, gentamicin and cisplatin) and liver (acetaminophen, rosiglitazone, fluconazole and isoniazid). After performing gene expression analysis and hierarchical clustering, signature patterns for the two classes were obtained, with a set of 365 genes that can discriminate the two classes of drugs. Our results imply that transcriptional profile of hPBMC get altered as a consequence of drug exposure and unique patterns indicative of specific organ toxicity can hence be deduced. These signature patterns obtained for drugs could be studied for their qualification to identify drug-induced toxicity." @default.
• W2059090970 created "2016-06-24" @default.
• W2059090970 creator A5002800136 @default.
• W2059090970 creator A5021095306 @default.
• W2059090970 creator A5052869079 @default.
• W2059090970 creator A5064839442 @default.
• W2059090970 creator A5086907298 @default.
• W2059090970 creator A5089588763 @default.
• W2059090970 date "2010-10-01" @default.
• W2059090970 modified "2023-10-17" @default.
• W2059090970 title "Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells" @default.
• W2059090970 cites W1535615952 @default.
• W2059090970 cites W1965606609 @default.
• W2059090970 cites W1969221700 @default.
• W2059090970 cites W1990564998 @default.
• W2059090970 cites W1990572691 @default.
• W2059090970 cites W1997129449 @default.
• W2059090970 cites W1999330408 @default.
• W2059090970 cites W2013722813 @default.
• W2059090970 cites W2024673727 @default.
• W2059090970 cites W2025207792 @default.
• W2059090970 cites W2025711350 @default.
• W2059090970 cites W2032659701 @default.
• W2059090970 cites W2034841018 @default.
• W2059090970 cites W2040007196 @default.
• W2059090970 cites W2056933088 @default.
• W2059090970 cites W2069924791 @default.
• W2059090970 cites W2070783015 @default.
• W2059090970 cites W2072041551 @default.
• W2059090970 cites W2096269949 @default.
• W2059090970 cites W2114502253 @default.
• W2059090970 cites W2117154043 @default.
• W2059090970 cites W2129271267 @default.
• W2059090970 cites W2141341794 @default.
• W2059090970 cites W2143352223 @default.
• W2059090970 cites W2165482500 @default.
• W2059090970 doi "https://doi.org/10.1016/j.bbrc.2010.09.039" @default.
• W2059090970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20849824" @default.
• W2059090970 hasPublicationYear "2010" @default.
• W2059090970 type Work @default.
• W2059090970 sameAs 2059090970 @default.
• W2059090970 citedByCount "10" @default.
• W2059090970 countsByYear W20590909702012 @default.
• W2059090970 countsByYear W20590909702013 @default.
• W2059090970 countsByYear W20590909702014 @default.
• W2059090970 countsByYear W20590909702018 @default.
• W2059090970 crossrefType "journal-article" @default.
• W2059090970 hasAuthorship W2059090970A5002800136 @default.
• W2059090970 hasAuthorship W2059090970A5021095306 @default.
• W2059090970 hasAuthorship W2059090970A5052869079 @default.
• W2059090970 hasAuthorship W2059090970A5064839442 @default.
• W2059090970 hasAuthorship W2059090970A5086907298 @default.
• W2059090970 hasAuthorship W2059090970A5089588763 @default.
• W2059090970 hasConcept C104317684 @default.
• W2059090970 hasConcept C126322002 @default.
• W2059090970 hasConcept C137061746 @default.
• W2059090970 hasConcept C150194340 @default.
• W2059090970 hasConcept C162317418 @default.
• W2059090970 hasConcept C202751555 @default.
• W2059090970 hasConcept C2779733811 @default.
• W2059090970 hasConcept C2780035454 @default.
• W2059090970 hasConcept C29730261 @default.
• W2059090970 hasConcept C54355233 @default.
• W2059090970 hasConcept C71924100 @default.
• W2059090970 hasConcept C86803240 @default.
• W2059090970 hasConcept C93231420 @default.
• W2059090970 hasConcept C98274493 @default.
• W2059090970 hasConceptScore W2059090970C104317684 @default.
• W2059090970 hasConceptScore W2059090970C126322002 @default.
• W2059090970 hasConceptScore W2059090970C137061746 @default.
• W2059090970 hasConceptScore W2059090970C150194340 @default.
• W2059090970 hasConceptScore W2059090970C162317418 @default.
• W2059090970 hasConceptScore W2059090970C202751555 @default.
• W2059090970 hasConceptScore W2059090970C2779733811 @default.
• W2059090970 hasConceptScore W2059090970C2780035454 @default.
• W2059090970 hasConceptScore W2059090970C29730261 @default.
• W2059090970 hasConceptScore W2059090970C54355233 @default.
• W2059090970 hasConceptScore W2059090970C71924100 @default.
• W2059090970 hasConceptScore W2059090970C86803240 @default.
• W2059090970 hasConceptScore W2059090970C93231420 @default.
• W2059090970 hasConceptScore W2059090970C98274493 @default.
• W2059090970 hasIssue "2" @default.
• W2059090970 hasLocation W20590909701 @default.
• W2059090970 hasLocation W20590909702 @default.
• W2059090970 hasOpenAccess W2059090970 @default.
• W2059090970 hasPrimaryLocation W20590909701 @default.
• W2059090970 hasRelatedWork W1971124177 @default.
• W2059090970 hasRelatedWork W2009966535 @default.
• W2059090970 hasRelatedWork W2023487034 @default.
• W2059090970 hasRelatedWork W2107661394 @default.
• W2059090970 hasRelatedWork W2116016263 @default.
• W2059090970 hasRelatedWork W2353446510 @default.
• W2059090970 hasRelatedWork W3089353767 @default.
• W2059090970 hasRelatedWork W3097825150 @default.
• W2059090970 hasRelatedWork W3146618441 @default.
• W2059090970 hasRelatedWork W4247273247 @default.
• W2059090970 hasVolume "401" @default.
• W2059090970 isParatext "false" @default.

• next