FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059091090> ?p ?o ?g. }

• W2059091090 endingPage "327" @default.
• W2059091090 startingPage "317" @default.
• W2059091090 abstract "In vitro effects of three triorganotins--tributyltin (TBT), triethyltin (TET), and trimethyltin (TMT)--on calmodulin (CaM) activity were studied. Stimulation of Ca2(+)-ATPase of rat brain synaptic membranes and phosphodiesterase (PDE) of bovine brain were assayed as indicators of CaM activity. The rat synaptic membranes were prepared and CaM was depleted by washing with 1 mM EGTA. All the three organotins inhibited the basal as well as CaM-stimulated Ca2(+)-ATPase in a concentration-dependent manner, suggesting their interaction with calcium pump. However, CaM-stimulated Ca2(+)-ATPase was more sensitive than the basal enzyme. The order of potency of the three organotin compounds was TBT greater than TET greater than TMT. The IC50 values of Ca2(+)-ATPase (basal) were 0.63, 35, and approximately 800 microM, respectively, whereas the values for CaM-stimulated Ca2(+)-ATPase were 0.05, 0.8, and 18 microM for TBT, TET, and TMT, respectively. CaM-deficient PDE did not show any sensitivity to these three organotin compounds, while TBT and TET significantly decreased the CaM-stimulated PDE activity. TMT, which was the least effective inhibitor of Ca2+ pump, did not alter PDE activity. Further, the inhibition of CaM-stimulated Ca2(+)-ATPase activity by these organotins could be reversed by excess addition of CaM. These results suggest that the organotins interact with CaM activity, as evidenced by their potent effect on CaM-dependent Ca2(+)-ATPase and PDE activities." @default.
• W2059091090 created "2016-06-24" @default.
• W2059091090 creator A5006880829 @default.
• W2059091090 creator A5007350826 @default.
• W2059091090 creator A5089251312 @default.
• W2059091090 date "1990-03-01" @default.
• W2059091090 modified "2023-10-12" @default.
• W2059091090 title "Differential effects of triorganotins on calmodulin activity" @default.
• W2059091090 cites W1188688487 @default.
• W2059091090 cites W1512693490 @default.
• W2059091090 cites W1516204830 @default.
• W2059091090 cites W1543414173 @default.
• W2059091090 cites W1588660075 @default.
• W2059091090 cites W1775749144 @default.
• W2059091090 cites W1965977400 @default.
• W2059091090 cites W1967096717 @default.
• W2059091090 cites W1968255141 @default.
• W2059091090 cites W1973113376 @default.
• W2059091090 cites W1981166080 @default.
• W2059091090 cites W1990080386 @default.
• W2059091090 cites W1999315584 @default.
• W2059091090 cites W2025966227 @default.
• W2059091090 cites W2030669640 @default.
• W2059091090 cites W2048526825 @default.
• W2059091090 cites W2053887995 @default.
• W2059091090 cites W2088658487 @default.
• W2059091090 cites W2094373300 @default.
• W2059091090 cites W2117398313 @default.
• W2059091090 cites W2126044062 @default.
• W2059091090 cites W2126920933 @default.
• W2059091090 cites W2141587571 @default.
• W2059091090 cites W2293570720 @default.
• W2059091090 cites W2335740120 @default.
• W2059091090 cites W2481105393 @default.
• W2059091090 cites W2483724218 @default.
• W2059091090 cites W4249183788 @default.
• W2059091090 doi "https://doi.org/10.1080/15287399009531394" @default.
• W2059091090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2156084" @default.
• W2059091090 hasPublicationYear "1990" @default.
• W2059091090 type Work @default.
• W2059091090 sameAs 2059091090 @default.
• W2059091090 citedByCount "28" @default.
• W2059091090 countsByYear W20590910902012 @default.
• W2059091090 countsByYear W20590910902015 @default.
• W2059091090 crossrefType "journal-article" @default.
• W2059091090 hasAuthorship W2059091090A5006880829 @default.
• W2059091090 hasAuthorship W2059091090A5007350826 @default.
• W2059091090 hasAuthorship W2059091090A5089251312 @default.
• W2059091090 hasConcept C134018914 @default.
• W2059091090 hasConcept C178790620 @default.
• W2059091090 hasConcept C181199279 @default.
• W2059091090 hasConcept C185592680 @default.
• W2059091090 hasConcept C202751555 @default.
• W2059091090 hasConcept C23265538 @default.
• W2059091090 hasConcept C24998067 @default.
• W2059091090 hasConcept C2777658833 @default.
• W2059091090 hasConcept C2779078112 @default.
• W2059091090 hasConcept C29688787 @default.
• W2059091090 hasConcept C519063684 @default.
• W2059091090 hasConcept C55493867 @default.
• W2059091090 hasConcept C57992300 @default.
• W2059091090 hasConcept C62826618 @default.
• W2059091090 hasConcept C86803240 @default.
• W2059091090 hasConcept C98274493 @default.
• W2059091090 hasConceptScore W2059091090C134018914 @default.
• W2059091090 hasConceptScore W2059091090C178790620 @default.
• W2059091090 hasConceptScore W2059091090C181199279 @default.
• W2059091090 hasConceptScore W2059091090C185592680 @default.
• W2059091090 hasConceptScore W2059091090C202751555 @default.
• W2059091090 hasConceptScore W2059091090C23265538 @default.
• W2059091090 hasConceptScore W2059091090C24998067 @default.
• W2059091090 hasConceptScore W2059091090C2777658833 @default.
• W2059091090 hasConceptScore W2059091090C2779078112 @default.
• W2059091090 hasConceptScore W2059091090C29688787 @default.
• W2059091090 hasConceptScore W2059091090C519063684 @default.
• W2059091090 hasConceptScore W2059091090C55493867 @default.
• W2059091090 hasConceptScore W2059091090C57992300 @default.
• W2059091090 hasConceptScore W2059091090C62826618 @default.
• W2059091090 hasConceptScore W2059091090C86803240 @default.
• W2059091090 hasConceptScore W2059091090C98274493 @default.
• W2059091090 hasIssue "3" @default.
• W2059091090 hasLocation W20590910901 @default.
• W2059091090 hasLocation W20590910902 @default.
• W2059091090 hasOpenAccess W2059091090 @default.
• W2059091090 hasPrimaryLocation W20590910901 @default.
• W2059091090 hasRelatedWork W131335327 @default.
• W2059091090 hasRelatedWork W1561729644 @default.
• W2059091090 hasRelatedWork W1840326104 @default.
• W2059091090 hasRelatedWork W2008346915 @default.
• W2059091090 hasRelatedWork W2024589487 @default.
• W2059091090 hasRelatedWork W2040930963 @default.
• W2059091090 hasRelatedWork W2265438201 @default.
• W2059091090 hasRelatedWork W2350267216 @default.
• W2059091090 hasRelatedWork W2395411246 @default.
• W2059091090 hasRelatedWork W955179056 @default.
• W2059091090 hasVolume "29" @default.
• W2059091090 isParatext "false" @default.
• W2059091090 isRetracted "false" @default.

• next