Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059091154> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2059091154 endingPage "683" @default.
- W2059091154 startingPage "679" @default.
- W2059091154 abstract "The antabuse reaction, seen in patients imbibing alcohol while being treated with an antidiabetic sulfonylurea, is thought to be due to either an increase in acetaldehyde levels or an alteration in the metabolism of serotonin. Both can occur through an inhibition of aldehyde dehydrogenase. The oral antidiabetic sulfonylureas, chlorpropamide and tolbutamide, were found to be noncompetitive inhibitors of this enzyme. Acetaldehyde, a metabolite of ethanol, can competitively inhibit aldehyde dehydrogenase. Moreover, the oxidation of ethanol reverses the DPN/DPNH ratio so that the favored pathway of serotonin metabolism is altered, resulting in a decrease of 5-hydroxyindoleacetic acid (5-HIAA) and an increase of 5-hydroxytryptophol. Thus, ethanol augments the action of the sulfonylureas. Whether the syndrome results from an accumulation of acetaldehyde due to a block in ethanol metabolism, or whether it is a result of an alteration in the metabolism of serotonin, the noncompetitive inhibition of aldehyde dehydrogenase by the sulfonylureas, coupled with the actions of ethanol, may be considered as a potential cause." @default.
- W2059091154 created "2016-06-24" @default.
- W2059091154 creator A5059165002 @default.
- W2059091154 creator A5062971039 @default.
- W2059091154 date "1968-11-01" @default.
- W2059091154 modified "2023-10-16" @default.
- W2059091154 title "Biochemical Basis of the Sulfonylurea-induced Antabuse Syndrome" @default.
- W2059091154 doi "https://doi.org/10.2337/diab.17.11.679" @default.
- W2059091154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5687344" @default.
- W2059091154 hasPublicationYear "1968" @default.
- W2059091154 type Work @default.
- W2059091154 sameAs 2059091154 @default.
- W2059091154 citedByCount "49" @default.
- W2059091154 countsByYear W20590911542016 @default.
- W2059091154 crossrefType "journal-article" @default.
- W2059091154 hasAuthorship W2059091154A5059165002 @default.
- W2059091154 hasAuthorship W2059091154A5062971039 @default.
- W2059091154 hasConcept C126322002 @default.
- W2059091154 hasConcept C134018914 @default.
- W2059091154 hasConcept C181199279 @default.
- W2059091154 hasConcept C185592680 @default.
- W2059091154 hasConcept C25747580 @default.
- W2059091154 hasConcept C2776054734 @default.
- W2059091154 hasConcept C2777344606 @default.
- W2059091154 hasConcept C2777477808 @default.
- W2059091154 hasConcept C2777595113 @default.
- W2059091154 hasConcept C2778523461 @default.
- W2059091154 hasConcept C2778689066 @default.
- W2059091154 hasConcept C2778854520 @default.
- W2059091154 hasConcept C2779306644 @default.
- W2059091154 hasConcept C2780161600 @default.
- W2059091154 hasConcept C30153976 @default.
- W2059091154 hasConcept C55493867 @default.
- W2059091154 hasConcept C555293320 @default.
- W2059091154 hasConcept C62231903 @default.
- W2059091154 hasConcept C71924100 @default.
- W2059091154 hasConcept C98274493 @default.
- W2059091154 hasConceptScore W2059091154C126322002 @default.
- W2059091154 hasConceptScore W2059091154C134018914 @default.
- W2059091154 hasConceptScore W2059091154C181199279 @default.
- W2059091154 hasConceptScore W2059091154C185592680 @default.
- W2059091154 hasConceptScore W2059091154C25747580 @default.
- W2059091154 hasConceptScore W2059091154C2776054734 @default.
- W2059091154 hasConceptScore W2059091154C2777344606 @default.
- W2059091154 hasConceptScore W2059091154C2777477808 @default.
- W2059091154 hasConceptScore W2059091154C2777595113 @default.
- W2059091154 hasConceptScore W2059091154C2778523461 @default.
- W2059091154 hasConceptScore W2059091154C2778689066 @default.
- W2059091154 hasConceptScore W2059091154C2778854520 @default.
- W2059091154 hasConceptScore W2059091154C2779306644 @default.
- W2059091154 hasConceptScore W2059091154C2780161600 @default.
- W2059091154 hasConceptScore W2059091154C30153976 @default.
- W2059091154 hasConceptScore W2059091154C55493867 @default.
- W2059091154 hasConceptScore W2059091154C555293320 @default.
- W2059091154 hasConceptScore W2059091154C62231903 @default.
- W2059091154 hasConceptScore W2059091154C71924100 @default.
- W2059091154 hasConceptScore W2059091154C98274493 @default.
- W2059091154 hasIssue "11" @default.
- W2059091154 hasLocation W20590911541 @default.
- W2059091154 hasLocation W20590911542 @default.
- W2059091154 hasOpenAccess W2059091154 @default.
- W2059091154 hasPrimaryLocation W20590911541 @default.
- W2059091154 hasRelatedWork W2028897690 @default.
- W2059091154 hasRelatedWork W2046180758 @default.
- W2059091154 hasRelatedWork W2074674172 @default.
- W2059091154 hasRelatedWork W2095387098 @default.
- W2059091154 hasRelatedWork W2114594954 @default.
- W2059091154 hasRelatedWork W2120348522 @default.
- W2059091154 hasRelatedWork W2126408020 @default.
- W2059091154 hasRelatedWork W2158281900 @default.
- W2059091154 hasRelatedWork W2415977209 @default.
- W2059091154 hasRelatedWork W4251169362 @default.
- W2059091154 hasVolume "17" @default.
- W2059091154 isParatext "false" @default.
- W2059091154 isRetracted "false" @default.
- W2059091154 magId "2059091154" @default.
- W2059091154 workType "article" @default.